A defined syphilis vaccine candidate inhibits dissemination of Treponema pallidum subspecies pallidum

Karen V. Lithgow, Rebecca Hof, Charmaine Wetherell, Drew Phillips, Simon Houston and Caroline E. Cameron ()
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Karen V. Lithgow: University of Victoria
Rebecca Hof: University of Victoria
Charmaine Wetherell: University of Victoria
Drew Phillips: University of Victoria
Simon Houston: University of Victoria
Caroline E. Cameron: University of Victoria

Nature Communications, 2017, vol. 8, issue 1, 1-10

Abstract: Abstract Syphilis is a prominent disease in low- and middle-income countries, and a re-emerging public health threat in high-income countries. Syphilis elimination will require development of an effective vaccine that has thus far remained elusive. Here we assess the vaccine potential of Tp0751, a vascular adhesin from the causative agent of syphilis, Treponema pallidum subsp. pallidum. Tp0751-immunized animals exhibit a significantly reduced bacterial organ burden upon T. pallidum challenge compared with unimmunized animals. Introduction of lymph nodes from Tp0751-immunized, T. pallidum-challenged animals to naive animals fails to induce infection, confirming sterile protection. These findings provide evidence that Tp0751 is a promising syphilis vaccine candidate.

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14273

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DOI: 10.1038/ncomms14273

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