Cryptic bioactivity capacitated by synthetic hybrid plant peptides

Yuki Hirakawa, Hidefumi Shinohara, Kai Welke, Stephan Irle, Yoshikatsu Matsubayashi, Keiko U. Torii () and Naoyuki Uchida ()
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Yuki Hirakawa: Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Furo-cho
Hidefumi Shinohara: Graduate School of Science, Nagoya University
Kai Welke: Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Furo-cho
Stephan Irle: Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Furo-cho
Yoshikatsu Matsubayashi: Graduate School of Science, Nagoya University
Keiko U. Torii: Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Furo-cho
Naoyuki Uchida: Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Furo-cho

Nature Communications, 2017, vol. 8, issue 1, 1-7

Abstract: Abstract Evolution often diversifies a peptide hormone family into multiple subfamilies, which exert distinct activities by exclusive interaction with specific receptors. Here we show that systematic swapping of pre-existing variation in a subfamily of plant CLE peptide hormones leads to a synthetic bifunctional peptide that exerts activities beyond the original subfamily by interacting with multiple receptors. This approach provides new insights into the complexity and specificity of peptide signalling.

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14318

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DOI: 10.1038/ncomms14318

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