The molecular basis of endothelial cell plasticity

Elisabetta Dejana (), Karen K. Hirschi () and Michael Simons ()
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Elisabetta Dejana: Vascular Biology Unit, FIRC Institute of Molecular Oncology
Karen K. Hirschi: Yale Cardiovasc. Res. Center, Genetics and Biomedical Engineering
Michael Simons: Yale Cardiovascular Research Center, Yale University School of Medicine

Nature Communications, 2017, vol. 8, issue 1, 1-11

Abstract: The endothelium is capable of remarkable plasticity. In the embryo, primitive endothelial cells differentiate to acquire arterial, venous or lymphatic fates. Certain endothelial cells also undergo hematopoietic transition giving rise to multi-lineage hematopoietic stem and progenitors while others acquire mesenchymal properties necessary for heart development. In the adult, maintenance of differentiated endothelial state is an active process requiring constant signalling input. The failure to do so leads to the development of endothelial-to-mesenchymal transition that plays an important role in pathogenesis of a number of diseases. A better understanding of these phenotypic changes may lead to development of new therapeutic interventions.

Date: 2017
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DOI: 10.1038/ncomms14361

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