Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential

Evan Bardot, Damelys Calderon, Francis Santoriello, Songyan Han, Kakit Cheung, Bharati Jadhav, Ingo Burtscher, Stanley Artap, Rajan Jain, Jonathan Epstein, Heiko Lickert, Valerie Gouon-Evans, Andrew J. Sharp and Nicole C. Dubois ()
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Evan Bardot: Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai
Damelys Calderon: Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai
Francis Santoriello: Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai
Songyan Han: Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai
Kakit Cheung: Icahn School of Medicine at Mount Sinai
Bharati Jadhav: Icahn School of Medicine at Mount Sinai
Ingo Burtscher: Institute of Diabetes and Regeneration Research at the Helmholtz Zentrum München, German Center for Diabetes Research (DZD)
Stanley Artap: Cardiovascular Institute, University of Pennsylvania
Rajan Jain: Cardiovascular Institute, University of Pennsylvania
Jonathan Epstein: Cardiovascular Institute, University of Pennsylvania
Heiko Lickert: Institute of Diabetes and Regeneration Research at the Helmholtz Zentrum München, German Center for Diabetes Research (DZD)
Valerie Gouon-Evans: Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai
Andrew J. Sharp: Icahn School of Medicine at Mount Sinai
Nicole C. Dubois: Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai

Nature Communications, 2017, vol. 8, issue 1, 1-15

Abstract: Abstract The recent identification of progenitor populations that contribute to the developing heart in a distinct spatial and temporal manner has fundamentally improved our understanding of cardiac development. However, the mechanisms that direct atrial versus ventricular specification remain largely unknown. Here we report the identification of a progenitor population that gives rise primarily to cardiovascular cells of the ventricles and only to few atrial cells (

Date: 2017
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DOI: 10.1038/ncomms14428

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