A genome-wide association study yields five novel thyroid cancer risk loci

Julius Gudmundsson (), Gudmar Thorleifsson, Jon K. Sigurdsson, Lilja Stefansdottir, Jon G. Jonasson, Sigurjon A. Gudjonsson, Daniel F. Gudbjartsson, Gisli Masson, Hrefna Johannsdottir, Gisli H. Halldorsson, Simon N. Stacey, Hannes Helgason, Patrick Sulem, Leigha Senter, Huiling He, Sandya Liyanarachchi, Matthew D. Ringel, Esperanza Aguillo, Angeles Panadero, Enrique Prats, Almudena Garcia-Castaño, Ana De Juan, Fernando Rivera, Li Xu, Lambertus A. Kiemeney, Gudmundur I. Eyjolfsson, Olof Sigurdardottir, Isleifur Olafsson, Hoskuldur Kristvinsson, Romana T. Netea-Maier, Thorvaldur Jonsson, Jose I. Mayordomo, Theo S. Plantinga, Hannes Hjartarson, Jon Hrafnkelsson, Erich M. Sturgis, Unnur Thorsteinsdottir, Thorunn Rafnar, Albert de la Chapelle and Kari Stefansson ()
Additional contact information
Julius Gudmundsson: deCODE genetics/AMGEN
Gudmar Thorleifsson: deCODE genetics/AMGEN
Jon K. Sigurdsson: deCODE genetics/AMGEN
Lilja Stefansdottir: deCODE genetics/AMGEN
Jon G. Jonasson: Landspitali-University Hospital
Sigurjon A. Gudjonsson: deCODE genetics/AMGEN
Daniel F. Gudbjartsson: deCODE genetics/AMGEN
Gisli Masson: deCODE genetics/AMGEN
Hrefna Johannsdottir: deCODE genetics/AMGEN
Gisli H. Halldorsson: deCODE genetics/AMGEN
Simon N. Stacey: deCODE genetics/AMGEN
Hannes Helgason: deCODE genetics/AMGEN
Patrick Sulem: deCODE genetics/AMGEN
Leigha Senter: Ohio State University Comprehensive Cancer Center
Huiling He: Ohio State University Comprehensive Cancer Center
Sandya Liyanarachchi: Ohio State University Comprehensive Cancer Center
Matthew D. Ringel: Diabetes, and Metabolism, The Ohio State University
Esperanza Aguillo: University Hospital
Angeles Panadero: Ciudad de Coria Hospital
Enrique Prats: University Hospital
Almudena Garcia-Castaño: Marques de Valdecilla University Hospital
Ana De Juan: Marques de Valdecilla University Hospital
Fernando Rivera: Marques de Valdecilla University Hospital
Li Xu: The University of Texas MD Anderson Cancer Center
Lambertus A. Kiemeney: Radboud University Medical Centre, Radboud Institute for Health Sciences
Gudmundur I. Eyjolfsson: The Laboratory in Mjodd
Olof Sigurdardottir: Akureyri Hospital
Isleifur Olafsson: Landspitali-University Hospital
Hoskuldur Kristvinsson: Landspitali-University Hospital
Romana T. Netea-Maier: Radboud University Medical Centre, Radboud Institute for Health Sciences
Thorvaldur Jonsson: Landspitali-University Hospital
Jose I. Mayordomo: University of Colorado Hospital
Theo S. Plantinga: Radboud University Medical Center, Radboud Institute for Molecular Life Sciences
Hannes Hjartarson: Landspitali-University Hospital
Jon Hrafnkelsson: Landspitali-University Hospital
Erich M. Sturgis: The University of Texas MD Anderson Cancer Center
Unnur Thorsteinsdottir: deCODE genetics/AMGEN
Thorunn Rafnar: deCODE genetics/AMGEN
Albert de la Chapelle: Ohio State University Comprehensive Cancer Center
Kari Stefansson: deCODE genetics/AMGEN

Nature Communications, 2017, vol. 8, issue 1, 1-8

Abstract: Abstract The great majority of thyroid cancers are of the non-medullary type. Here we report findings from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patients and 287,550 controls from five study groups of European descent. Our results yield five novel loci (all with Pcombined

Date: 2017
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DOI: 10.1038/ncomms14517

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