Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

Marcus Lefebure, Richard W. Tothill (), Elizabeth Kruse, Edwin D. Hawkins, Jake Shortt, Geoffrey M. Matthews, Gareth P. Gregory, Benjamin P. Martin, Madison J. Kelly, Izabela Todorovski, Maria A. Doyle, Richard Lupat, Jason Li, Jan Schroeder, Meaghan Wall, Stuart Craig, Gretchen Poortinga, Don Cameron, Megan Bywater, Lev Kats, Micah D. Gearhart, Vivian J. Bardwell, Ross A. Dickins, Ross D. Hannan, Anthony T. Papenfuss and Ricky W. Johnstone ()
Additional contact information
Marcus Lefebure: The Peter MacCallum Cancer Centre
Richard W. Tothill: The Peter MacCallum Cancer Centre
Elizabeth Kruse: The Peter MacCallum Cancer Centre
Edwin D. Hawkins: The Walter Eliza Hall Institute of Medical Research
Jake Shortt: The Peter MacCallum Cancer Centre
Geoffrey M. Matthews: Dana Farber Cancer Institute
Gareth P. Gregory: The Peter MacCallum Cancer Centre
Benjamin P. Martin: The Peter MacCallum Cancer Centre
Madison J. Kelly: The Peter MacCallum Cancer Centre
Izabela Todorovski: The Peter MacCallum Cancer Centre
Maria A. Doyle: The Peter MacCallum Cancer Centre
Richard Lupat: The Peter MacCallum Cancer Centre
Jason Li: The Peter MacCallum Cancer Centre
Jan Schroeder: The Walter Eliza Hall Institute of Medical Research
Meaghan Wall: Victorian Cancer Cytogenetics Service, St Vincent’s Hospital
Stuart Craig: The Peter MacCallum Cancer Centre
Gretchen Poortinga: The Peter MacCallum Cancer Centre
Don Cameron: The Peter MacCallum Cancer Centre
Megan Bywater: The Peter MacCallum Cancer Centre
Lev Kats: The Peter MacCallum Cancer Centre
Micah D. Gearhart: Developmental Biology Center, Masonic Cancer Center, Cell Biology, and Development, University of Minnesota
Vivian J. Bardwell: Developmental Biology Center, Masonic Cancer Center, Cell Biology, and Development, University of Minnesota
Ross A. Dickins: Australian Centre for Blood Diseases, Monash University
Ross D. Hannan: The Peter MacCallum Cancer Centre
Anthony T. Papenfuss: The Peter MacCallum Cancer Centre
Ricky W. Johnstone: The Peter MacCallum Cancer Centre

Nature Communications, 2017, vol. 8, issue 1, 1-10

Abstract: Abstract The Eμ-Myc mouse is an extensively used model of MYC driven malignancy; however to date there has only been partial characterization of MYC co-operative mutations leading to spontaneous lymphomagenesis. Here we sequence spontaneously arising Eμ-Myc lymphomas to define transgene architecture, somatic mutations, and structural alterations. We identify frequent disruptive mutations in the PRC1-like component and BCL6-corepressor gene Bcor. Moreover, we find unexpected concomitant multigenic lesions involving Cdkn2a loss and other cancer genes including Nras, Kras and Bcor. These findings challenge the assumed two-hit model of Eμ-Myc lymphoma and demonstrate a functional in vivo role for Bcor in suppressing tumorigenesis.

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14581

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DOI: 10.1038/ncomms14581

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