Evolution of complexity in the zebrafish synapse proteome

Àlex Bayés (), Mark O. Collins, Rita Reig-Viader, Gemma Gou, David Goulding, Abril Izquierdo, Jyoti S. Choudhary, Richard D. Emes and Seth G. N. Grant ()
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Àlex Bayés: Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau (IIB Sant Pau)
Mark O. Collins: The Centre for Membrane Interactions and Dynamics, University of Sheffield, Western Bank
Rita Reig-Viader: Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau (IIB Sant Pau)
Gemma Gou: Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau (IIB Sant Pau)
David Goulding: Pathogen Genomics, Wellcome Trust Sanger Institute
Abril Izquierdo: School of Veterinary Medicine and Science, University of Nottingham. Sutton Bonington Campus
Jyoti S. Choudhary: Proteomic Mass Spectrometry, The Wellcome Trust Sanger Institute
Richard D. Emes: School of Veterinary Medicine and Science, University of Nottingham. Sutton Bonington Campus
Seth G. N. Grant: Genes to Cognition Programme, Centre for Clinical Brain Science, University of Edinburgh

Nature Communications, 2017, vol. 8, issue 1, 1-15

Abstract: Abstract The proteome of human brain synapses is highly complex and is mutated in over 130 diseases. This complexity arose from two whole-genome duplications early in the vertebrate lineage. Zebrafish are used in modelling human diseases; however, its synapse proteome is uncharacterized, and whether the teleost-specific genome duplication (TSGD) influenced complexity is unknown. We report the characterization of the proteomes and ultrastructure of central synapses in zebrafish and analyse the importance of the TSGD. While the TSGD increases overall synapse proteome complexity, the postsynaptic density (PSD) proteome of zebrafish has lower complexity than mammals. A highly conserved set of ∼1,000 proteins is shared across vertebrates. PSD ultrastructural features are also conserved. Lineage-specific proteome differences indicate that vertebrate species evolved distinct synapse types and functions. The data sets are a resource for a wide range of studies and have important implications for the use of zebrafish in modelling human synaptic diseases.

Date: 2017
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DOI: 10.1038/ncomms14613

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