DNA methylation signatures in peripheral blood strongly predict all-cause mortality

Yan Zhang (), Rory Wilson, Jonathan Heiss, Lutz P. Breitling, Kai-Uwe Saum, Ben Schöttker, Bernd Holleczek, Melanie Waldenberger, Annette Peters and Hermann Brenner
Additional contact information
Yan Zhang: German Research Cancer Research Center (DKFZ)
Rory Wilson: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Center for Environmental Health
Jonathan Heiss: German Research Cancer Research Center (DKFZ)
Lutz P. Breitling: German Research Cancer Research Center (DKFZ)
Kai-Uwe Saum: German Research Cancer Research Center (DKFZ)
Ben Schöttker: German Research Cancer Research Center (DKFZ)
Bernd Holleczek: Saarland Cancer Registry
Melanie Waldenberger: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Center for Environmental Health
Annette Peters: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Center for Environmental Health
Hermann Brenner: German Research Cancer Research Center (DKFZ)

Nature Communications, 2017, vol. 8, issue 1, 1-11

Abstract: Abstract DNA methylation (DNAm) has been revealed to play a role in various diseases. Here we performed epigenome-wide screening and validation to identify mortality-related DNAm signatures in a general population-based cohort with up to 14 years follow-up. In the discovery panel in a case-cohort approach, 11,063 CpGs reach genome-wide significance (FDR

Date: 2017
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DOI: 10.1038/ncomms14617

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