Management of E. coli sister chromatid cohesion in response to genotoxic stress

Elise Vickridge, Charlene Planchenault, Charlotte Cockram, Isabel Garcia Junceda and Olivier Espéli ()
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Elise Vickridge: Center for Interdisciplinary Research in Biology (CIRB), Collège de France, UMR CNRS-7241, INSERM U1050, PSL Research University
Charlene Planchenault: Center for Interdisciplinary Research in Biology (CIRB), Collège de France, UMR CNRS-7241, INSERM U1050, PSL Research University
Charlotte Cockram: Center for Interdisciplinary Research in Biology (CIRB), Collège de France, UMR CNRS-7241, INSERM U1050, PSL Research University
Isabel Garcia Junceda: Center for Interdisciplinary Research in Biology (CIRB), Collège de France, UMR CNRS-7241, INSERM U1050, PSL Research University
Olivier Espéli: Center for Interdisciplinary Research in Biology (CIRB), Collège de France, UMR CNRS-7241, INSERM U1050, PSL Research University

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract Aberrant DNA replication is a major source of the mutations and chromosomal rearrangements associated with pathological disorders. In bacteria, several different DNA lesions are repaired by homologous recombination, a process that involves sister chromatid pairing. Previous work in Escherichia coli has demonstrated that sister chromatid interactions (SCIs) mediated by topological links termed precatenanes, are controlled by topoisomerase IV. In the present work, we demonstrate that during the repair of mitomycin C-induced lesions, topological links are rapidly substituted by an SOS-induced sister chromatid cohesion process involving the RecN protein. The loss of SCIs and viability defects observed in the absence of RecN were compensated by alterations in topoisomerase IV, suggesting that the main role of RecN during DNA repair is to promote contacts between sister chromatids. RecN also modulates whole chromosome organization and RecA dynamics suggesting that SCIs significantly contribute to the repair of DNA double-strand breaks (DSBs).

Date: 2017
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DOI: 10.1038/ncomms14618

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