Sfrp5 identifies murine cardiac progenitors for all myocardial structures except for the right ventricle

Masayuki Fujii, Akane Sakaguchi, Ryo Kamata, Masataka Nagao, Yutaka Kikuchi, Silvia M. Evans, Masao Yoshizumi, Akihiko Shimono, Yumiko Saga () and Hiroki Kokubo ()
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Masayuki Fujii: Graduate School of Biomedical and Health Sciences, Hiroshima University
Akane Sakaguchi: National Institute of Genetics, Mishima 411-8540 Japan
Ryo Kamata: Graduate School of Biomedical and Health Sciences, Hiroshima University
Masataka Nagao: Graduate School of Biomedical and Health Sciences, Hiroshima University
Yutaka Kikuchi: Graduate School of Science, Hiroshima University
Silvia M. Evans: School of Medicine UC San Diego
Masao Yoshizumi: Graduate School of Biomedical and Health Sciences, Hiroshima University
Akihiko Shimono: Center for Developmental Biology (CDB), RIKEN Kobe
Yumiko Saga: National Institute of Genetics, Mishima 411-8540 Japan
Hiroki Kokubo: Graduate School of Biomedical and Health Sciences, Hiroshima University

Nature Communications, 2017, vol. 8, issue 1, 1-9

Abstract: Abstract Upon acquirement of pulmonary circulation, the ancestral heart may have been remodelled coincidently with, or accompanied by, the production and rearrangement of progenitor cells. However, the progenitor populations that give rise to the left ventricle (LV) and sinus venosus (SV) are still ambiguous. Here we show that the expression of Secreted frizzled-related protein Sfrp5 in the mouse identifies common progenitors for the outflow tract (OFT), LV, atrium and SV but not the right ventricle (RV). Sfrp5 expression begins at the lateral sides of the cardiac crescent, excluding early differentiating regions, and continues in the venous pole, which gives rise to the SV. Lineage-tracing analysis revealed that descendants of Sfrp5-expressing cells at E7.5 contribute not only to the SV but also to the LV, atria and OFT and are found also in the dorsal splanchnic mesoderm accompanied by the expression of the secondary heart field marker, Islet1. These findings provide insight into the arrangement of cardiac progenitors for systemic circulation.

Date: 2017
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DOI: 10.1038/ncomms14664

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