Defining stem cell dynamics and migration during wound healing in mouse skin epidermis

Mariaceleste Aragona, Sophie Dekoninck, Steffen Rulands, Sandrine Lenglez, Guilhem Mascré, Benjamin D. Simons and Cédric Blanpain ()
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Mariaceleste Aragona: Université Libre de Bruxelles, IRIBHM
Sophie Dekoninck: Université Libre de Bruxelles, IRIBHM
Steffen Rulands: Cavendish Laboratory, University of Cambridge
Sandrine Lenglez: Université Libre de Bruxelles, IRIBHM
Guilhem Mascré: Université Libre de Bruxelles, IRIBHM
Benjamin D. Simons: Cavendish Laboratory, University of Cambridge
Cédric Blanpain: Université Libre de Bruxelles, IRIBHM

Nature Communications, 2017, vol. 8, issue 1, 1-14

Abstract: Abstract Wound healing is essential to repair the skin after injury. In the epidermis, distinct stem cells (SCs) populations contribute to wound healing. However, how SCs balance proliferation, differentiation and migration to repair a wound remains poorly understood. Here, we show the cellular and molecular mechanisms that regulate wound healing in mouse tail epidermis. Using a combination of proliferation kinetics experiments and molecular profiling, we identify the gene signatures associated with proliferation, differentiation and migration in different regions surrounding the wound. Functional experiments show that SC proliferation, migration and differentiation can be uncoupled during wound healing. Lineage tracing and quantitative clonal analysis reveal that, following wounding, progenitors divide more rapidly, but conserve their homoeostatic mode of division, leading to their rapid depletion, whereas SCs become active, giving rise to new progenitors that expand and repair the wound. These results have important implications for tissue regeneration, acute and chronic wound disorders.

Date: 2017
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DOI: 10.1038/ncomms14684

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