Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness

Stefanie Heilmann-Heimbach (), Christine Herold, Lara M. Hochfeld, Axel M. Hillmer, Dale R. Nyholt, Julian Hecker, Asif Javed, Elaine G. Y. Chew, Sonali Pechlivanis, Dmitriy Drichel, Xiu Ting Heng, Ricardo C. -H. del Rosario, Heide L. Fier, Ralf Paus, Rico Rueedi, Tessel E. Galesloot, Susanne Moebus, Thomas Anhalt, Shyam Prabhakar, Rui Li, Stavroula Kanoni, George Papanikolaou, Zoltán Kutalik, Panos Deloukas, Michael P. Philpott, Gérard Waeber, Tim D. Spector, Peter Vollenweider, Lambertus A. L. M. Kiemeney, George Dedoussis, J. Brent Richards, Michael Nothnagel, Nicholas G. Martin, Tim Becker, David A. Hinds and Markus M. Nöthen ()
Additional contact information
Stefanie Heilmann-Heimbach: Institute of Human Genetics, University of Bonn
Christine Herold: German Center for Neurodegenerative Disorders
Lara M. Hochfeld: Institute of Human Genetics, University of Bonn
Axel M. Hillmer: Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore
Dale R. Nyholt: Institute of Health and Biomedical Innovation, Queensland University of Technology
Julian Hecker: Institute of Genomic Mathematics, University of Bonn
Asif Javed: Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore
Elaine G. Y. Chew: Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore
Sonali Pechlivanis: Institute of Medical Informatics, Biometry and Epidemiology, Medical Faculty, University of Duisburg-Essen
Dmitriy Drichel: Cologne Center for Genomics, University of Cologne
Xiu Ting Heng: Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore
Ricardo C. -H. del Rosario: Computational and Systems Biology, Genome Institute of Singapore
Heide L. Fier: Institute of Genomic Mathematics, University of Bonn
Ralf Paus: Dermatology Research Centre, Institute of Inflammation and Repair, University of Manchester
Rico Rueedi: University of Lausanne
Tessel E. Galesloot: Radboud Institute for Health Sciences, Radboud University Medical Center
Susanne Moebus: Institute of Medical Informatics, Biometry and Epidemiology, Medical Faculty, University of Duisburg-Essen
Thomas Anhalt: Institute of Human Genetics, University of Bonn
Shyam Prabhakar: Computational and Systems Biology, Genome Institute of Singapore
Rui Li: Centre for Clinical Epidemiology, Genetics and Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University
Stavroula Kanoni: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
George Papanikolaou: School of Health Sciences and Education, Harokopio University
Zoltán Kutalik: Swiss Institute of Bioinformatics
Panos Deloukas: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Michael P. Philpott: Centre for Cell Biology and Cutaneous Research Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Gérard Waeber: Lausanne University Hospital (CHUV)
Tim D. Spector: King's College London
Peter Vollenweider: Lausanne University Hospital (CHUV)
Lambertus A. L. M. Kiemeney: Radboud Institute for Health Sciences, Radboud University Medical Center
George Dedoussis: School of Health Sciences and Education, Harokopio University
J. Brent Richards: Centre for Clinical Epidemiology, Genetics and Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University
Michael Nothnagel: Cologne Center for Genomics, University of Cologne
Nicholas G. Martin: QIMR Berghofer Medical Research Institute
Tim Becker: Institute for Community Medicine, Ernst Moritz Arndt University Greifswald
David A. Hinds: 23andMe Inc.
Markus M. Nöthen: Institute of Human Genetics, University of Bonn

Nature Communications, 2017, vol. 8, issue 1, 1-8

Abstract: Abstract Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We identify 63 MPB-associated loci (P

Date: 2017
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DOI: 10.1038/ncomms14694

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