Optical imaging of localized chemical events using programmable diamond quantum nanosensors

Torsten Rendler, Jitka Neburkova, Ondrej Zemek, Jan Kotek, Andrea Zappe, Zhiqin Chu (), Petr Cigler () and Jörg Wrachtrup
Additional contact information
Torsten Rendler: 3. Physikalisches Institut, Universität Stuttgart
Jitka Neburkova: Institute of Organic Chemistry and Biochemistry of the CAS
Ondrej Zemek: Faculty of Science, Charles University
Jan Kotek: Faculty of Science, Charles University
Andrea Zappe: 3. Physikalisches Institut, Universität Stuttgart
Zhiqin Chu: 3. Physikalisches Institut, Universität Stuttgart
Petr Cigler: Institute of Organic Chemistry and Biochemistry of the CAS
Jörg Wrachtrup: 3. Physikalisches Institut, Universität Stuttgart

Nature Communications, 2017, vol. 8, issue 1, 1-9

Abstract: Abstract Development of multifunctional nanoscale sensors working under physiological conditions enables monitoring of intracellular processes that are important for various biological and medical applications. By attaching paramagnetic gadolinium complexes to nanodiamonds (NDs) with nitrogen-vacancy (NV) centres through surface engineering, we developed a hybrid nanoscale sensor that can be adjusted to directly monitor physiological species through a proposed sensing scheme based on NV spin relaxometry. We adopt a single-step method to measure spin relaxation rates enabling time-dependent measurements on changes in pH or redox potential at a submicrometre-length scale in a microfluidic channel that mimics cellular environments. Our experimental data are reproduced by numerical simulations of the NV spin interaction with gadolinium complexes covering the NDs. Considering the versatile engineering options provided by polymer chemistry, the underlying mechanism can be expanded to detect a variety of physiologically relevant species and variables.

Date: 2017
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms14701 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14701

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms14701

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().