Cell-matrix adhesion and cell-cell adhesion differentially control basal myosin oscillation and Drosophila egg chamber elongation

Xiang Qin, Byung Ouk Park, Jiaying Liu, Bing Chen, Valerie Choesmel-Cadamuro, Karine Belguise, Won Do Heo () and Xiaobo Wang ()
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Xiang Qin: LBCMCP, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS
Byung Ouk Park: Center for Cognition and Sociality, Institute for Basic Science (IBS)
Jiaying Liu: LBCMCP, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS
Bing Chen: LBCMCP, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS
Valerie Choesmel-Cadamuro: LBCMCP, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS
Karine Belguise: LBCMCP, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS
Won Do Heo: Center for Cognition and Sociality, Institute for Basic Science (IBS)
Xiaobo Wang: LBCMCP, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS

Nature Communications, 2017, vol. 8, issue 1, 1-16

Abstract: Abstract Pulsatile actomyosin contractility, important in tissue morphogenesis, has been studied mainly in apical but less in basal domains. Basal myosin oscillation underlying egg chamber elongation is regulated by both cell–matrix and cell–cell adhesions. However, the mechanism by which these two adhesions govern basal myosin oscillation and tissue elongation is unknown. Here we demonstrate that cell–matrix adhesion positively regulates basal junctional Rho1 activity and medio-basal ROCK and myosin activities, thus strongly controlling tissue elongation. Differently, cell–cell adhesion governs basal myosin oscillation through controlling medio-basal distributions of both ROCK and myosin signals, which are related to the spatial limitations of cell–matrix adhesion and stress fibres. Contrary to cell–matrix adhesion, cell–cell adhesion weakly affects tissue elongation. In vivo optogenetic protein inhibition spatiotemporally confirms the different effects of these two adhesions on basal myosin oscillation. This study highlights the activity and distribution controls of basal myosin contractility mediated by cell–matrix and cell–cell adhesions, respectively, during tissue morphogenesis.

Date: 2017
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DOI: 10.1038/ncomms14708

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