Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity

Koenraad Philippaert, Andy Pironet, Margot Mesuere, William Sones, Laura Vermeiren, Sara Kerselaers, Sílvia Pinto, Andrei Segal, Nancy Antoine, Conny Gysemans, Jos Laureys, Katleen Lemaire, Patrick Gilon, Eva Cuypers, Jan Tytgat, Chantal Mathieu, Frans Schuit, Patrik Rorsman, Karel Talavera, Thomas Voets and Rudi Vennekens ()
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Koenraad Philippaert: Laboratory of Ion Channel Research, KU Leuven
Andy Pironet: Laboratory of Ion Channel Research, KU Leuven
Margot Mesuere: Laboratory of Ion Channel Research, KU Leuven
William Sones: Oxford Centre for Diabetes, Endocrinology and Metabolism
Laura Vermeiren: Laboratory of Ion Channel Research, KU Leuven
Sara Kerselaers: Laboratory of Ion Channel Research, KU Leuven
Sílvia Pinto: Laboratory of Ion Channel Research, KU Leuven
Andrei Segal: Laboratory of Ion Channel Research, KU Leuven
Nancy Antoine: Pôle d'endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain
Conny Gysemans: Clinical and Experimental Endocrinology, KU Leuven
Jos Laureys: Clinical and Experimental Endocrinology, KU Leuven
Katleen Lemaire: Gene Expression Unit, KU Leuven
Patrick Gilon: Pôle d'endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain
Eva Cuypers: Toxicology and Pharmacology, KU Leuven
Jan Tytgat: Toxicology and Pharmacology, KU Leuven
Chantal Mathieu: Clinical and Experimental Endocrinology, KU Leuven
Frans Schuit: Gene Expression Unit, KU Leuven
Patrik Rorsman: Oxford Centre for Diabetes, Endocrinology and Metabolism
Karel Talavera: Laboratory of Ion Channel Research, KU Leuven
Thomas Voets: Laboratory of Ion Channel Research, KU Leuven
Rudi Vennekens: Laboratory of Ion Channel Research, KU Leuven

Nature Communications, 2017, vol. 8, issue 1, 1-16

Abstract: Abstract Steviol glycosides (SGs), such as stevioside and rebaudioside A, are natural, non-caloric sweet-tasting organic molecules, present in extracts of the scrub plant Stevia rebaudiana, which are widely used as sweeteners in consumer foods and beverages. TRPM5 is a Ca2+-activated cation channel expressed in type II taste receptor cells and pancreatic β-cells. Here we show that stevioside, rebaudioside A and their aglycon steviol potentiate the activity of TRPM5. We find that SGs potentiate perception of bitter, sweet and umami taste, and enhance glucose-induced insulin secretion in a Trpm5-dependent manner. Daily consumption of stevioside prevents development of high-fat-diet-induced diabetic hyperglycaemia in wild-type mice, but not in Trpm5−/− mice. These results elucidate a molecular mechanism of action of SGs and identify TRPM5 as a potential target to prevent and treat type 2 diabetes.

Date: 2017
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DOI: 10.1038/ncomms14733

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