Light-sensing via hydrogen peroxide and a peroxiredoxin

Kristofer Bodvard, Ken Peeters, Friederike Roger, Natalie Romanov, Aeid Igbaria, Niek Welkenhuysen, Gaël Palais, Wolfgang Reiter, Michel B. Toledano, Mikael Käll and Mikael Molin ()
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Kristofer Bodvard: University of Gothenburg
Ken Peeters: University of Gothenburg
Friederike Roger: University of Gothenburg
Natalie Romanov: Mass Spectrometry Facility, Max F. Perutz Laboratories, University of Vienna
Aeid Igbaria: Oxidative Stress and Cancer, SBIGEM, iBiTec-S, FRE3377 CEA-CNRS-Université Paris-Sud
Niek Welkenhuysen: University of Gothenburg
Gaël Palais: Oxidative Stress and Cancer, SBIGEM, iBiTec-S, FRE3377 CEA-CNRS-Université Paris-Sud
Wolfgang Reiter: Max F. Perutz Laboratories, University of Vienna
Michel B. Toledano: Oxidative Stress and Cancer, SBIGEM, iBiTec-S, FRE3377 CEA-CNRS-Université Paris-Sud
Mikael Käll: Chalmers University of Technology
Mikael Molin: University of Gothenburg

Nature Communications, 2017, vol. 8, issue 1, 1-11

Abstract: Abstract Yeast lacks dedicated photoreceptors; however, blue light still causes pronounced oscillations of the transcription factor Msn2 into and out of the nucleus. Here we show that this poorly understood phenomenon is initiated by a peroxisomal oxidase, which converts light into a hydrogen peroxide (H2O2) signal that is sensed by the peroxiredoxin Tsa1 and transduced to thioredoxin, to counteract PKA-dependent Msn2 phosphorylation. Upon H2O2, the nuclear retention of PKA catalytic subunits, which contributes to delayed Msn2 nuclear concentration, is antagonized in a Tsa1-dependent manner. Conversely, peroxiredoxin hyperoxidation interrupts the H2O2 signal and drives Msn2 oscillations by superimposing on PKA feedback regulation. Our data identify a mechanism by which light could be sensed in all cells lacking dedicated photoreceptors. In particular, the use of H2O2 as a second messenger in signalling is common to Msn2 oscillations and to light-induced entrainment of circadian rhythms and suggests conserved roles for peroxiredoxins in endogenous rhythms.

Date: 2017
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DOI: 10.1038/ncomms14791

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