Extinct type of human parvovirus B19 persists in tonsillar B cells

Lari Pyöriä, Mari Toppinen, Elina Mäntylä, Lea Hedman, Leena-Maija Aaltonen, Maija Vihinen-Ranta, Taru Ilmarinen, Maria Söderlund-Venermo, Klaus Hedman and Maria F. Perdomo ()
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Lari Pyöriä: University of Helsinki
Mari Toppinen: University of Helsinki
Elina Mäntylä: and Nanoscience Center, University of Jyväskylä
Lea Hedman: University of Helsinki
Leena-Maija Aaltonen: Helsinki University Hospital
Maija Vihinen-Ranta: and Nanoscience Center, University of Jyväskylä
Taru Ilmarinen: Helsinki University Hospital
Maria Söderlund-Venermo: University of Helsinki
Klaus Hedman: University of Helsinki
Maria F. Perdomo: University of Helsinki

Nature Communications, 2017, vol. 8, issue 1, 1-9

Abstract: Abstract Parvovirus B19 (B19V) DNA persists lifelong in human tissues, but the cell type harbouring it remains unclear. We here explore B19V DNA distribution in B, T and monocyte cell lineages of recently excised tonsillar tissues from 77 individuals with an age range of 2–69 years. We show that B19V DNA is most frequent and abundant among B cells, and within them we find a B19V genotype that vanished from circulation >40 years ago. Since re-infection or re-activation are unlikely with this virus type, this finding supports the maintenance of pathogen-specific humoral immune responses as a consequence of B-cell long-term survival rather than continuous replenishment of the memory pool. Moreover, we demonstrate the mechanism of B19V internalization to be antibody dependent in two B-cell lines as well as in ex vivo isolated tonsillar B cells. This study provides direct evidence for a cell type accountable for B19V DNA tissue persistence.

Date: 2017
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DOI: 10.1038/ncomms14930

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