Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Anne E. Justice (), Thomas W. Winkler, Mary F. Feitosa, Misa Graff, Virginia A. Fisher, Kristin Young, Llilda Barata, Xuan Deng, Jacek Czajkowski, David Hadley, Julius S. Ngwa, Tarunveer S. Ahluwalia, Audrey Y. Chu, Nancy L. Heard-Costa, Elise Lim, Jeremiah Perez, John D. Eicher, Zoltán Kutalik, Luting Xue, Anubha Mahajan, Frida Renström, Joseph Wu, Qibin Qi, Shafqat Ahmad, Tamuno Alfred, Najaf Amin, Lawrence F. Bielak, Amelie Bonnefond, Jennifer Bragg, Gemma Cadby, Martina Chittani, Scott Coggeshall, Tanguy Corre, Nese Direk, Joel Eriksson, Krista Fischer, Mathias Gorski, Marie Neergaard Harder, Momoko Horikoshi, Tao Huang, Jennifer E. Huffman, Anne U. Jackson, Johanne Marie Justesen, Stavroula Kanoni, Leena Kinnunen, Marcus E. Kleber, Pirjo Komulainen, Meena Kumari, Unhee Lim, Jian'an Luan, Leo-Pekka Lyytikäinen, Massimo Mangino, Ani Manichaikul, Jonathan Marten, Rita P. S. Middelberg, Martina Müller-Nurasyid, Pau Navarro, Louis Pérusse, Natalia Pervjakova, Cinzia Sarti, Albert Vernon Smith, Jennifer A. Smith, Alena Stančáková, Rona J. Strawbridge, Heather M. Stringham, Yun Ju Sung, Toshiko Tanaka, Alexander Teumer, Stella Trompet, Sander W. van der Laan, Peter J. van der Most, Jana V. Van Vliet-Ostaptchouk, Sailaja L. Vedantam, Niek Verweij, Jacqueline M. Vink, Veronique Vitart, Ying Wu, Loic Yengo, Weihua Zhang, Jing Hua Zhao, Martina E. Zimmermann, Niha Zubair, Gonçalo R. Abecasis, Linda S. Adair, Saima Afaq, Uzma Afzal, Stephan J. L. Bakker, Traci M. Bartz, John Beilby, Richard N. Bergman, Sven Bergmann, Reiner Biffar, John Blangero, Eric Boerwinkle, Lori L. Bonnycastle, Erwin Bottinger, Daniele Braga, Brendan M. Buckley, Steve Buyske, Harry Campbell, John C. Chambers, Francis S. Collins, Joanne E. Curran, Gert J. de Borst, Anton J. M. de Craen, Eco J. C. de Geus, George Dedoussis, Graciela E. Delgado, Hester M. den Ruijter, Gudny Eiriksdottir, Anna L. Eriksson, Tõnu Esko, Jessica D. Faul, Ian Ford, Terrence Forrester, Karl Gertow, Bruna Gigante, Nicola Glorioso, Jian Gong, Harald Grallert, Tanja B. Grammer, Niels Grarup, Saskia Haitjema, Göran Hallmans, Anders Hamsten, Torben Hansen, Tamara B. Harris, Catharina A. Hartman, Maija Hassinen, Nicholas D. Hastie, Andrew C. Heath, Dena Hernandez, Lucia Hindorff, Lynne J. Hocking, Mette Hollensted, Oddgeir L. Holmen, Georg Homuth, Jouke Jan Hottenga, Jie Huang, Joseph Hung, Nina Hutri-Kähönen, Erik Ingelsson, Alan L. James, John-Olov Jansson, Marjo-Riitta Jarvelin, Min A. Jhun, Marit E. Jørgensen, Markus Juonala, Mika Kähönen, Magnus Karlsson, Heikki A. Koistinen, Ivana Kolcic, Genovefa Kolovou, Charles Kooperberg, Bernhard K. Krämer, Johanna Kuusisto, Kirsti Kvaløy, Timo A. Lakka, Claudia Langenberg, Lenore J. Launer, Karin Leander, Nanette R. Lee, Lars Lind, Cecilia M. Lindgren, Allan Linneberg, Stephane Lobbens, Marie Loh, Mattias Lorentzon, Robert Luben, Gitta Lubke, Anja Ludolph-Donislawski, Sara Lupoli, Pamela A. F. Madden, Reija Männikkö, Pedro Marques-Vidal, Nicholas G. Martin, Colin A. McKenzie, Barbara McKnight, Dan Mellström, Cristina Menni, Grant W. Montgomery, (Bill) Musk Aw, Narisu Narisu, Matthias Nauck, Ilja M. Nolte, Albertine J. Oldehinkel, Matthias Olden, Ken K. Ong, Sandosh Padmanabhan, Patricia A. Peyser, Charlotta Pisinger, David J. Porteous, Olli T. Raitakari, Tuomo Rankinen, D. C. Rao, Laura J. Rasmussen-Torvik, Rajesh Rawal, Treva Rice, Paul M. Ridker, Lynda M. Rose, Stephanie A. Bien, Igor Rudan, Serena Sanna, Mark A. Sarzynski, Naveed Sattar, Kai Savonen, David Schlessinger, Salome Scholtens, Claudia Schurmann, Robert A. Scott, Bengt Sennblad, Marten A. Siemelink, Günther Silbernagel, P Eline Slagboom, Harold Snieder, Jan A. Staessen, David J. Stott, Morris A. Swertz, Amy J. Swift, Kent D. Taylor, Bamidele O. Tayo, Barbara Thorand, Dorothee Thuillier, Jaakko Tuomilehto, Andre G. Uitterlinden, Liesbeth Vandenput, Marie-Claude Vohl, Henry Völzke, Judith M. Vonk, Gérard Waeber, Melanie Waldenberger, R. G. J. Westendorp, Sarah Wild, Gonneke Willemsen, Bruce H. R. Wolffenbuttel, Andrew Wong, Alan F. Wright, Wei Zhao, M Carola Zillikens, Damiano Baldassarre, Beverley Balkau, Stefania Bandinelli, Carsten A. Böger, Dorret I. Boomsma, Claude Bouchard, Marcel Bruinenberg, Daniel I. Chasman, Yii-DerIda Chen, Peter S. Chines, Richard S. Cooper, Francesco Cucca, Daniele Cusi, Ulf de Faire, Luigi Ferrucci, Paul W. Franks, Philippe Froguel, Penny Gordon-Larsen, Hans- Jörgen Grabe, Vilmundur Gudnason, Christopher A. Haiman, Caroline Hayward, Kristian Hveem, Andrew D. Johnson, J Wouter Jukema, Sharon L. R. Kardia, Mika Kivimaki, Jaspal S. Kooner, Diana Kuh, Markku Laakso, Terho Lehtimäki, Loic Le Marchand, Winfried März, Mark I. McCarthy, Andres Metspalu, Andrew P. Morris, Claes Ohlsson, Lyle J. Palmer, Gerard Pasterkamp, Oluf Pedersen, Annette Peters, Ulrike Peters, Ozren Polasek, Bruce M. Psaty, Lu Qi, Rainer Rauramaa, Blair H. Smith, Thorkild I. A. Sørensen, Konstantin Strauch, Henning Tiemeier, Elena Tremoli, Pim van der Harst, Henrik Vestergaard, Peter Vollenweider, Nicholas J. Wareham, David R. Weir, John B. Whitfield, James F. Wilson, Jessica Tyrrell, Timothy M. Frayling, Inês Barroso, Michael Boehnke, Panagiotis Deloukas, Caroline S. Fox, Joel N. Hirschhorn, David J. Hunter, Tim D. Spector, David P. Strachan, Cornelia M. van Duijn, Iris M. Heid, Karen L. Mohlke, Jonathan Marchini, Ruth J. F. Loos, Tuomas O. Kilpeläinen, Ching-Ti Liu, Ingrid B. Borecki, Kari E. North and L Adrienne Cupples ()
Additional contact information
Anne E. Justice: University of North Carolina
Thomas W. Winkler: Institute of Epidemiology and Preventive Medicine, University of Regensburg
Mary F. Feitosa: Washington University School of Medicine
Misa Graff: University of North Carolina
Virginia A. Fisher: Boston University School of Public Health
Kristin Young: University of North Carolina
Llilda Barata: Washington University School of Medicine
Xuan Deng: Boston University School of Public Health
Jacek Czajkowski: Washington University School of Medicine
David Hadley: Population Health Research Institute, St. George's, University of London
Julius S. Ngwa: Boston University School of Public Health
Tarunveer S. Ahluwalia: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
Audrey Y. Chu: NHLBI Framingham Heart Study
Nancy L. Heard-Costa: NHLBI Framingham Heart Study
Elise Lim: Boston University School of Public Health
Jeremiah Perez: Boston University School of Public Health
John D. Eicher: Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, The Framingham Heart Study
Zoltán Kutalik: Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV)
Luting Xue: Boston University School of Public Health
Anubha Mahajan: Wellcome Trust Centre for Human Genetics, University of Oxford
Frida Renström: Umeå University
Joseph Wu: Boston University School of Public Health
Qibin Qi: Albert Einstein College of Medicine
Shafqat Ahmad: Brigham and Women's Hospital and Harvard Medical School
Tamuno Alfred: The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
Najaf Amin: Genetic Epidemiology Unit, Erasmus University Medical Center
Lawrence F. Bielak: School of Public Health, University of Michigan
Amelie Bonnefond: University of Lille, CNRS, Institut Pasteur of Lille, UMR 8199 - EGID
Jennifer Bragg: Internal Medicine - Nephrology, University of Michigan
Gemma Cadby: Centre for Genetic Origins of Health and Disease, University of Western Australia
Martina Chittani: University of Milan
Scott Coggeshall: University of Washington
Tanguy Corre: Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV)
Nese Direk: Erasmus Medical Center
Joel Eriksson: Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg
Krista Fischer: Estonian Genome Center, University of Tartu
Mathias Gorski: Institute of Epidemiology and Preventive Medicine, University of Regensburg
Marie Neergaard Harder: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
Momoko Horikoshi: Wellcome Trust Centre for Human Genetics, University of Oxford
Tao Huang: Harvard T.H. Chan School of Public Health
Jennifer E. Huffman: Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, The Framingham Heart Study
Anne U. Jackson: University of Michigan
Johanne Marie Justesen: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
Stavroula Kanoni: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Leena Kinnunen: National Institute for Health and Welfare
Marcus E. Kleber: Medical Faculty Mannheim, Heidelberg University
Pirjo Komulainen: Kuopio Research Institute of Exercise Medicine
Meena Kumari: ISER, University of Essex
Unhee Lim: Epidemiology Program, University of Hawaii Cancer Center
Jian'an Luan: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science
Leo-Pekka Lyytikäinen: Fimlab Laboratories
Massimo Mangino: King’s College London
Ani Manichaikul: Center for Public Health Genomics and Biostatistics Section, University of Virginia
Jonathan Marten: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Rita P. S. Middelberg: Genetic Epidemiology, QIMR Berghofer Medical Research Institute
Martina Müller-Nurasyid: Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health
Pau Navarro: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Louis Pérusse: Faculty of Medicine, Université Laval
Natalia Pervjakova: Estonian Genome Center, University of Tartu
Cinzia Sarti: City of Helsinki
Albert Vernon Smith: Icelandic Heart Association
Jennifer A. Smith: School of Public Health, University of Michigan
Alena Stančáková: Institute of Clinical Medicine, University of Eastern Finland
Rona J. Strawbridge: Cardiovascular Medicine Unit, Karolinska Institutet
Heather M. Stringham: University of Michigan
Yun Ju Sung: Washington University School of Medicine
Toshiko Tanaka: Translational Gerontology Branch, National Institute on Aging
Alexander Teumer: Institute for Community Medicine, University Medicine Greifswald
Stella Trompet: Leiden University Medical Center
Sander W. van der Laan: Laboratory of Experimental Cardiology, UMC Utrecht
Peter J. van der Most: University of Groningen, University Medical Center Groningen
Jana V. Van Vliet-Ostaptchouk: University of Groningen, University Medical Center Groningen
Sailaja L. Vedantam: Boston Children's Hospital
Niek Verweij: University Medical Center Groningen, University of Groningen
Jacqueline M. Vink: Vrije Universiteit
Veronique Vitart: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Ying Wu: University of North Carolina
Loic Yengo: University of Lille, CNRS, Institut Pasteur of Lille, UMR 8199 - EGID
Weihua Zhang: Dept Epidemiology and Biostatistics, School of Public Health, Imperical College London
Jing Hua Zhao: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science
Martina E. Zimmermann: Institute of Epidemiology and Preventive Medicine, University of Regensburg
Niha Zubair: Fred Hutchinson Cancer Research Center
Gonçalo R. Abecasis: University of Michigan
Linda S. Adair: Gillings School of Global Public Health, University of North Carolina at Chapel Hill
Saima Afaq: Dept Epidemiology and Biostatistics, School of Public Health, Imperical College London
Uzma Afzal: Dept Epidemiology and Biostatistics, School of Public Health, Imperical College London
Stephan J. L. Bakker: University Medical Center Groningen, University of Groningen
Traci M. Bartz: University of Washington
John Beilby: Busselton Population Medical Research Institute
Richard N. Bergman: Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center
Sven Bergmann: University of Lausanne
Reiner Biffar: Clinic for Prosthetic Dentistry, Gerostomatology and Material Science, University Medicine Greifswald
John Blangero: South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley
Eric Boerwinkle: Human Genetics Center, The University of Texas Health Science Center
Lori L. Bonnycastle: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH
Erwin Bottinger: The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
Daniele Braga: University of Milan
Brendan M. Buckley: University College Cork
Steve Buyske: Rutgers University
Harry Campbell: Usher Institute for Population Health Sciences and Informatics, The University of Edinburgh
John C. Chambers: Dept Epidemiology and Biostatistics, School of Public Health, Imperical College London
Francis S. Collins: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH
Joanne E. Curran: South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley
Gert J. de Borst: UMC Utrecht
Anton J. M. de Craen: Leiden University Medical Center
Eco J. C. de Geus: Vrije Universiteit
George Dedoussis: School of Health Science and Education, Harokopio University
Graciela E. Delgado: Medical Faculty Mannheim, Heidelberg University
Hester M. den Ruijter: Laboratory of Experimental Cardiology, UMC Utrecht
Gudny Eiriksdottir: Icelandic Heart Association
Anna L. Eriksson: Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg
Tõnu Esko: Estonian Genome Center, University of Tartu
Jessica D. Faul: Survey Research Center, Institute for Social Research, University of Michigan
Ian Ford: Robertson Centre for Biostatistics, University of Glasgow
Terrence Forrester: Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies
Karl Gertow: Cardiovascular Medicine Unit, Karolinska Institutet
Bruna Gigante: Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet
Nicola Glorioso: Hypertension and Related Disease Centre, AOU-University of Sassari
Jian Gong: Fred Hutchinson Cancer Research Center
Harald Grallert: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
Tanja B. Grammer: Medical Faculty Mannheim, Heidelberg University
Niels Grarup: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
Saskia Haitjema: Laboratory of Experimental Cardiology, UMC Utrecht
Göran Hallmans: Section for Nutritional Research, Umeå University
Anders Hamsten: Cardiovascular Medicine Unit, Karolinska Institutet
Torben Hansen: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
Tamara B. Harris: Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health
Catharina A. Hartman: Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Centre Groningen
Maija Hassinen: Kuopio Research Institute of Exercise Medicine
Nicholas D. Hastie: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Andrew C. Heath: Washington University School of Medicine
Dena Hernandez: Laboratory of Neurogenetics, National Institute on Aging
Lucia Hindorff: National Human Genome Research Institute, National Institutes of Health
Lynne J. Hocking: Institute of Medical Sciences, University of Aberdeen, Foresterhill
Mette Hollensted: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
Oddgeir L. Holmen: St. Olav Hospital, Trondheim University Hospital
Georg Homuth: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
Jouke Jan Hottenga: Vrije Universiteit
Jie Huang: Wellcome Trust Sanger Institute
Joseph Hung: School of Medicine and Pharmacology, The University of Western Australia
Nina Hutri-Kähönen: Tampere University Hospital
Erik Ingelsson: Molecular Epidemiology, Uppsala University
Alan L. James: Busselton Population Medical Research Institute
John-Olov Jansson: Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg
Marjo-Riitta Jarvelin: MRC–PHE Centre for Environment & Health, School of Public Health, Imperial College London
Min A. Jhun: School of Public Health, University of Michigan
Marit E. Jørgensen: Steno Diabetes Center
Markus Juonala: University of Turku
Mika Kähönen: Tampere University Hospital
Magnus Karlsson: Clinical and Molecular Osteoporosis Research Unit, Skåne University Hospital, Lund University
Heikki A. Koistinen: National Institute for Health and Welfare
Ivana Kolcic: Faculty of Medicine, University of Split
Genovefa Kolovou: Onassis Cardiac Surgery Center
Charles Kooperberg: Fred Hutchinson Cancer Research Center
Bernhard K. Krämer: Medical Faculty Mannheim, Heidelberg University
Johanna Kuusisto: University of Eastern Finland and Kuopio University Hospital
Kirsti Kvaløy: HUNT Research Centre, Norwegian University of Science and Technology
Timo A. Lakka: Kuopio Research Institute of Exercise Medicine
Claudia Langenberg: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science
Lenore J. Launer: Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health
Karin Leander: Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet
Nanette R. Lee: USC-Office of Population Studies Foundation, Inc., University of San Carlos
Lars Lind: Cardiovascular Epidemiology, Uppsala University
Cecilia M. Lindgren: Wellcome Trust Centre for Human Genetics, University of Oxford
Allan Linneberg: Research Centre for Prevention and Health, the Capital Region of Denmark
Stephane Lobbens: University of Lille, CNRS, Institut Pasteur of Lille, UMR 8199 - EGID
Marie Loh: Dept Epidemiology and Biostatistics, School of Public Health, Imperical College London
Mattias Lorentzon: Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg
Robert Luben: University of Cambridge
Gitta Lubke: University of Notre Dame
Anja Ludolph-Donislawski: Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health
Sara Lupoli: University of Milan
Pamela A. F. Madden: Washington University School of Medicine
Reija Männikkö: Kuopio Research Institute of Exercise Medicine
Pedro Marques-Vidal: Internal Medicine, Lausanne university hospital (CHUV)
Nicholas G. Martin: Genetic Epidemiology, QIMR Berghofer Medical Research Institute
Colin A. McKenzie: Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies
Barbara McKnight: University of Washington
Dan Mellström: Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg
Cristina Menni: King’s College London
Grant W. Montgomery: Molecular Epidemiology, QIMR Berghofer Medical Research Institute
(Bill) Musk Aw: Busselton Population Medical Research Institute
Narisu Narisu: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH
Matthias Nauck: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald
Ilja M. Nolte: University of Groningen, University Medical Center Groningen
Albertine J. Oldehinkel: Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Centre Groningen
Matthias Olden: Institute of Epidemiology and Preventive Medicine, University of Regensburg
Ken K. Ong: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science
Sandosh Padmanabhan: Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh
Patricia A. Peyser: School of Public Health, University of Michigan
Charlotta Pisinger: Research Center for Prevention and Health, Glostrup Hospital
David J. Porteous: Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh
Olli T. Raitakari: Turku University Hospital
Tuomo Rankinen: Human Genomics Laboratory, Pennington Biomedical Research Center
D. C. Rao: Washington University School of Medicine
Laura J. Rasmussen-Torvik: Northwestern University Feinberg School of Medicine
Rajesh Rawal: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
Treva Rice: Washington University School of Medicine
Paul M. Ridker: Brigham and Women's Hospital and Harvard Medical School
Lynda M. Rose: Brigham and Women's Hospital and Harvard Medical School
Stephanie A. Bien: Fred Hutchinson Cancer Research Center
Igor Rudan: Usher Institute for Population Health Sciences and Informatics, The University of Edinburgh
Serena Sanna: Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale Delle Ricerche (CNR), Cittadella Universitaria di Monserrato
Mark A. Sarzynski: Human Genomics Laboratory, Pennington Biomedical Research Center
Naveed Sattar: BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine
Kai Savonen: Kuopio Research Institute of Exercise Medicine
David Schlessinger: Laboratory of Genetics, National Institute on Aging, National Institutes of Health
Salome Scholtens: University of Groningen, University Medical Center Groningen
Claudia Schurmann: The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
Robert A. Scott: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science
Bengt Sennblad: Cardiovascular Medicine Unit, Karolinska Institutet
Marten A. Siemelink: Laboratory of Experimental Cardiology, UMC Utrecht
Günther Silbernagel: Medical University of Graz
P Eline Slagboom: Leiden University Medical Center
Harold Snieder: University of Groningen, University Medical Center Groningen
Jan A. Staessen: Research Unit Hypertension and Cardiovascular Epidemiology, University of Leuven, Campus Sint Rafael
David J. Stott: Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow
Morris A. Swertz: University of Groningen, University Medical Center Groningen
Amy J. Swift: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH
Kent D. Taylor: Center for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor/UCLA Medical Center
Bamidele O. Tayo: Stritch School of Medicine, Loyola University of Chicago
Barbara Thorand: Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health
Dorothee Thuillier: University of Lille, CNRS, Institut Pasteur of Lille, UMR 8199 - EGID
Jaakko Tuomilehto: Dasman Diabetes Institute
Andre G. Uitterlinden: Erasmus Medical Center
Liesbeth Vandenput: Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg
Marie-Claude Vohl: Institute of Nutrition and Functional Foods, Université Laval
Henry Völzke: Institute for Community Medicine, University Medicine Greifswald
Judith M. Vonk: University of Groningen, University Medical Center Groningen
Gérard Waeber: Internal Medicine, Lausanne university hospital (CHUV)
Melanie Waldenberger: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
R. G. J. Westendorp: and Center for Healthy Ageing, University of Copenhagen
Sarah Wild: Usher Institute for Population Health Sciences and Informatics, The University of Edinburgh
Gonneke Willemsen: Vrije Universiteit
Bruce H. R. Wolffenbuttel: University of Groningen, University Medical Center Groningen
Andrew Wong: MRC Unit for Lifelong Health and Ageing at UCL
Alan F. Wright: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Wei Zhao: School of Public Health, University of Michigan
M Carola Zillikens: Erasmus Medical Center
Damiano Baldassarre: Università di Milano
Beverley Balkau: Inserm U-1018, CESP
Stefania Bandinelli: Geriatric Unit, Azienda USL Toscana centro
Carsten A. Böger: University Hospital Regensburg
Dorret I. Boomsma: Vrije Universiteit
Claude Bouchard: Human Genomics Laboratory, Pennington Biomedical Research Center
Marcel Bruinenberg: Lifelines Cohort Study
Daniel I. Chasman: Brigham and Women's Hospital and Harvard Medical School
Yii-DerIda Chen: Institute for Translational Genomics and Population Sciences, Harbor-UCLA
Peter S. Chines: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH
Richard S. Cooper: Stritch School of Medicine, Loyola University of Chicago
Francesco Cucca: Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale Delle Ricerche (CNR), Cittadella Universitaria di Monserrato
Daniele Cusi: Sanipedia srl, Bresso (Milano), Italy and Institute of Biomedical Technologies National Centre of Research Segrate
Ulf de Faire: Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet
Luigi Ferrucci: Translational Gerontology Branch, National Institute on Aging
Paul W. Franks: Genetic and Molecular Epidemiology Unit, Lund University
Philippe Froguel: University of Lille, CNRS, Institut Pasteur of Lille, UMR 8199 - EGID
Penny Gordon-Larsen: Gillings School of Global Public Health, University of North Carolina at Chapel Hill
Hans- Jörgen Grabe: University Medicine Greifswald
Vilmundur Gudnason: Icelandic Heart Association
Christopher A. Haiman: Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Caroline Hayward: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Kristian Hveem: HUNT Research Centre, Norwegian University of Science and Technology
Andrew D. Johnson: Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, The Framingham Heart Study
J Wouter Jukema: Leiden University Medical Center
Sharon L. R. Kardia: School of Public Health, University of Michigan
Mika Kivimaki: UCL
Jaspal S. Kooner: Cardiology, Ealing Hospital NHS Trust
Diana Kuh: MRC Unit for Lifelong Health and Ageing at UCL
Markku Laakso: University of Eastern Finland and Kuopio University Hospital
Terho Lehtimäki: Fimlab Laboratories
Loic Le Marchand: Epidemiology Program, University of Hawaii Cancer Center
Winfried März: Synlab Academy, Synlab Services GmbH
Mark I. McCarthy: Wellcome Trust Centre for Human Genetics, University of Oxford
Andres Metspalu: Estonian Genome Center, University of Tartu
Andrew P. Morris: Wellcome Trust Centre for Human Genetics, University of Oxford
Claes Ohlsson: Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg
Lyle J. Palmer: School of Public Health, University of Adelaide
Gerard Pasterkamp: Laboratory of Experimental Cardiology, UMC Utrecht
Oluf Pedersen: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
Annette Peters: Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health
Ulrike Peters: Fred Hutchinson Cancer Research Center
Ozren Polasek: Usher Institute for Population Health Sciences and Informatics, The University of Edinburgh
Bruce M. Psaty: University of Washington
Lu Qi: Harvard T.H. Chan School of Public Health
Rainer Rauramaa: Kuopio Research Institute of Exercise Medicine
Blair H. Smith: Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh
Thorkild I. A. Sørensen: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
Konstantin Strauch: Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health
Henning Tiemeier: Department of Psychiatry Erasmus Medical Center
Elena Tremoli: Università di Milano
Pim van der Harst: University Medical Center Groningen, University of Groningen
Henrik Vestergaard: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
Peter Vollenweider: Internal Medicine, Lausanne university hospital (CHUV)
Nicholas J. Wareham: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science
David R. Weir: Survey Research Center, Institute for Social Research, University of Michigan
John B. Whitfield: Genetic Epidemiology, QIMR Berghofer Medical Research Institute
James F. Wilson: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Jessica Tyrrell: Genetics of Complex Traits, University of Exeter Medical School, RILD Building University of Exeter
Timothy M. Frayling: Genetics of Complex Traits, University of Exeter Medical School, University of Exeter
Inês Barroso: Wellcome Trust Sanger Institute
Michael Boehnke: University of Michigan
Panagiotis Deloukas: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Caroline S. Fox: NHLBI Framingham Heart Study
Joel N. Hirschhorn: Boston Children's Hospital
David J. Hunter: Harvard T.H. Chan School of Public Health
Tim D. Spector: King’s College London
David P. Strachan: Population Health Research Institute, St. George's, University of London
Cornelia M. van Duijn: Genetic Epidemiology Unit, Erasmus University Medical Center
Iris M. Heid: Institute of Epidemiology and Preventive Medicine, University of Regensburg
Karen L. Mohlke: University of North Carolina
Jonathan Marchini: University of Oxford
Ruth J. F. Loos: The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
Tuomas O. Kilpeläinen: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
Ching-Ti Liu: Boston University School of Public Health
Ingrid B. Borecki: Washington University School of Medicine
Kari E. North: University of North Carolina
L Adrienne Cupples: Boston University School of Public Health

Nature Communications, 2017, vol. 8, issue 1, 1-19

Abstract: Abstract Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14977

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DOI: 10.1038/ncomms14977

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