Wearable smart sensor systems integrated on soft contact lenses for wireless ocular diagnostics

Joohee Kim, Minji Kim, Mi-Sun Lee, Kukjoo Kim, Sangyoon Ji, Yun-Tae Kim, Jihun Park, Kyungmin Na, Kwi-Hyun Bae, Hong Kyun Kim, Franklin Bien (), Chang Young Lee () and Jang-Ung Park ()
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Joohee Kim: School of Materials Science and Engineering, School of Energy and Chemical Engineering, Wearable Electronics Research Group, Center for Smart Sensor Systems, Ulsan National Institute of Science and Technology (UNIST)
Minji Kim: School of Materials Science and Engineering, School of Energy and Chemical Engineering, Wearable Electronics Research Group, Center for Smart Sensor Systems, Ulsan National Institute of Science and Technology (UNIST)
Mi-Sun Lee: School of Materials Science and Engineering, School of Energy and Chemical Engineering, Wearable Electronics Research Group, Center for Smart Sensor Systems, Ulsan National Institute of Science and Technology (UNIST)
Kukjoo Kim: School of Materials Science and Engineering, School of Energy and Chemical Engineering, Wearable Electronics Research Group, Center for Smart Sensor Systems, Ulsan National Institute of Science and Technology (UNIST)
Sangyoon Ji: School of Materials Science and Engineering, School of Energy and Chemical Engineering, Wearable Electronics Research Group, Center for Smart Sensor Systems, Ulsan National Institute of Science and Technology (UNIST)
Yun-Tae Kim: School of Life Sciences, School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST)
Jihun Park: School of Materials Science and Engineering, School of Energy and Chemical Engineering, Wearable Electronics Research Group, Center for Smart Sensor Systems, Ulsan National Institute of Science and Technology (UNIST)
Kyungmin Na: School of Electrical and Computer Engineering, Ulsan National Institute of Science and Technology (UNIST)
Kwi-Hyun Bae: Kyungpook National University School of Medicine
Hong Kyun Kim: Kyungpook National University School of Medicine
Franklin Bien: School of Electrical and Computer Engineering, Ulsan National Institute of Science and Technology (UNIST)
Chang Young Lee: School of Life Sciences, School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST)
Jang-Ung Park: School of Materials Science and Engineering, School of Energy and Chemical Engineering, Wearable Electronics Research Group, Center for Smart Sensor Systems, Ulsan National Institute of Science and Technology (UNIST)

Nature Communications, 2017, vol. 8, issue 1, 1-8

Abstract: Abstract Wearable contact lenses which can monitor physiological parameters have attracted substantial interests due to the capability of direct detection of biomarkers contained in body fluids. However, previously reported contact lens sensors can only monitor a single analyte at a time. Furthermore, such ocular contact lenses generally obstruct the field of vision of the subject. Here, we developed a multifunctional contact lens sensor that alleviates some of these limitations since it was developed on an actual ocular contact lens. It was also designed to monitor glucose within tears, as well as intraocular pressure using the resistance and capacitance of the electronic device. Furthermore, in-vivo and in-vitro tests using a live rabbit and bovine eyeball demonstrated its reliable operation. Our developed contact lens sensor can measure the glucose level in tear fluid and intraocular pressure simultaneously but yet independently based on different electrical responses.

Date: 2017
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DOI: 10.1038/ncomms14997

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