Dual-stimuli responsive and reversibly activatable theranostic nanoprobe for precision tumor-targeting and fluorescence-guided photothermal therapy

Xu Zhao, Cheng-Xiong Yang, Li-Gong Chen and Xiu-Ping Yan ()
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Xu Zhao: College of Chemistry, Research Center for Analytical Science, State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, Nankai University
Cheng-Xiong Yang: College of Chemistry, Research Center for Analytical Science, State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, Nankai University
Li-Gong Chen: Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)
Xiu-Ping Yan: College of Chemistry, Research Center for Analytical Science, State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, Nankai University

Nature Communications, 2017, vol. 8, issue 1, 1-9

Abstract: Abstract The integrated functions of diagnostics and therapeutics make theranostics great potential for personalized medicine. Stimulus-responsive therapy allows spatial control of therapeutic effect only in the site of interest, and offers promising opportunities for imaging-guided precision therapy. However, the imaging strategies in previous stimulus-responsive therapies are ‘always on’ or irreversible ‘turn on’ modality, resulting in poor signal-to-noise ratios or even ‘false positive’ results. Here we show the design of dual-stimuli-responsive and reversibly activatable nanoprobe for precision tumour-targeting and fluorescence-guided photothermal therapy. We fabricate the nanoprobe from asymmetric cyanine and glycosyl-functionalized gold nanorods (AuNRs) with matrix metalloproteinases (MMPs)-specific peptide as a linker to achieve MMPs/pH synergistic and pH reversible activation. The unique activation and glycosyl targetibility makes the nanoprobe bright only in tumour sites with negligible background, while AuNRs and asymmetric cyanine give synergistic photothermal effect. This work paves the way to designing efficient nanoprobes for precision theranostics.

Date: 2017
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DOI: 10.1038/ncomms14998

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