Implantable batteryless device for on-demand and pulsatile insulin administration

Seung Ho Lee, Young Bin Lee, Byung Hwi Kim, Cheol Lee, Young Min Cho, Se-Na Kim, Chun Gwon Park, Yong-Chan Cho and Young Bin Choy ()
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Seung Ho Lee: Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University
Young Bin Lee: Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University
Byung Hwi Kim: Seoul National University College of Medicine
Cheol Lee: Seoul National University College of Medicine
Young Min Cho: Seoul National University College of Medicine
Se-Na Kim: Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University
Chun Gwon Park: Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University
Yong-Chan Cho: Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University
Young Bin Choy: Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University

Nature Communications, 2017, vol. 8, issue 1, 1-10

Abstract: Abstract Many implantable systems have been designed for long-term, pulsatile delivery of insulin, but the lifetime of these devices is limited by the need for battery replacement and consequent replacement surgery. Here we propose a batteryless, fully implantable insulin pump that can be actuated by a magnetic field. The pump is prepared by simple-assembly of magnets and constituent units and comprises a drug reservoir and actuator equipped with a plunger and barrel, each assembled with a magnet. The plunger moves to noninvasively infuse insulin only when a magnetic field is applied on the exterior surface of the body. Here we show that the dose is easily controlled by varying the number of magnet applications. Also, pump implantation in diabetic rats results in profiles of insulin concentration and decreased blood glucose levels similar to those observed in rats treated with conventional subcutaneous insulin injections.

Date: 2017
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DOI: 10.1038/ncomms15032

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