Parvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation

Nicolette Ognjanovski, Samantha Schaeffer, Jiaxing Wu, Sima Mofakham, Daniel Maruyama, Michal Zochowski and Sara J. Aton ()
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Nicolette Ognjanovski: Cellular, and Developmental Biology, University of Michigan
Samantha Schaeffer: Cellular, and Developmental Biology, University of Michigan
Jiaxing Wu: Applied Physics Program, University of Michigan
Sima Mofakham: Biophysics Program, University of Michigan
Daniel Maruyama: Biophysics Program, University of Michigan
Michal Zochowski: Applied Physics Program, University of Michigan
Sara J. Aton: Cellular, and Developmental Biology, University of Michigan

Nature Communications, 2017, vol. 8, issue 1, 1-14

Abstract: Abstract Activity in hippocampal area CA1 is essential for consolidating episodic memories, but it is unclear how CA1 activity patterns drive memory formation. We find that in the hours following single-trial contextual fear conditioning (CFC), fast-spiking interneurons (which typically express parvalbumin (PV)) show greater firing coherence with CA1 network oscillations. Post-CFC inhibition of PV+ interneurons blocks fear memory consolidation. This effect is associated with loss of two network changes associated with normal consolidation: (1) augmented sleep-associated delta (0.5–4 Hz), theta (4–12 Hz) and ripple (150–250 Hz) oscillations; and (2) stabilization of CA1 neurons’ functional connectivity patterns. Rhythmic activation of PV+ interneurons increases CA1 network coherence and leads to a sustained increase in the strength and stability of functional connections between neurons. Our results suggest that immediately following learning, PV+ interneurons drive CA1 oscillations and reactivation of CA1 ensembles, which directly promotes network plasticity and long-term memory formation.

Date: 2017
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DOI: 10.1038/ncomms15039

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