Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti

Jinshu Xu, Hiroo Ueno, Chelsea Y. Xu, Binglai Chen, Irving L. Weissman and Pin-Xian Xu ()
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Jinshu Xu: Icahn School of Medicine at Mount Sinai
Hiroo Ueno: Institute of Stem Cell Biology and Regenerative Medicine, Stanford University
Chelsea Y. Xu: Icahn School of Medicine at Mount Sinai
Binglai Chen: Icahn School of Medicine at Mount Sinai
Irving L. Weissman: Institute of Stem Cell Biology and Regenerative Medicine, Stanford University
Pin-Xian Xu: Icahn School of Medicine at Mount Sinai

Nature Communications, 2017, vol. 8, issue 1, 1-17

Abstract: Abstract The adult mammalian cochlear sensory epithelium houses two major types of cells, mechanosensory hair cells and underlying supporting cells, and lacks regenerative capacity. Recent evidence indicates that a subset of supporting cells can spontaneously regenerate hair cells after ablation only within the first week postparturition. Here in vivo clonal analysis of mouse inner ear cells during development demonstrates clonal relationship between hair and supporting cells in sensory organs. We report the identification in mouse of a previously unknown population of multipotent stem/progenitor cells that are capable of not only contributing to the hair and supporting cells but also to other cell types, including glia, in cochlea undergoing development, maturation and repair in response to damage. These multipotent progenitors originate from Eya1-expressing otic progenitors. Our findings also provide evidence for detectable regenerative potential in the postnatal cochlea beyond 1 week of age.

Date: 2017
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DOI: 10.1038/ncomms15046

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