Transiently antigen-primed B cells return to naive-like state in absence of T-cell help

Jackson S. Turner, Matangi Marthi, Zachary L. Benet and Irina Grigorova ()
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Jackson S. Turner: University of Michigan Medical School
Matangi Marthi: University of Michigan Medical School
Zachary L. Benet: University of Michigan Medical School
Irina Grigorova: University of Michigan Medical School

Nature Communications, 2017, vol. 8, issue 1, 1-11

Abstract: Abstract The perspective that naive B-cell recognition of antigen in the absence of T-cell help causes cell death or anergy is supported by in vivo studies of B cells that are continuously exposed to self-antigens. However, intravital imaging suggests that early B-cell recognition of large foreign antigens may be transient. Whether B cells are tolerized or can be recruited into humoural immune responses following such encounters is not clear. Here we show that in the presence of T-cell help, single transient antigen acquisition is sufficient to recruit B cells into the germinal centre and induce memory and plasma cell responses. In the absence of T-cell help, transiently antigen-primed B cells do not undergo apoptosis in vivo; they return to quiescence and are recruited efficiently into humoural responses upon reacquisition of antigen and T-cell help.

Date: 2017
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DOI: 10.1038/ncomms15072

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