Lamin B1 is required for mature neuron-specific gene expression during olfactory sensory neuron differentiation

Crystal M. Gigante, Michele Dibattista, Frederick N. Dong, Xiaobin Zheng, Sibiao Yue, Stephen G. Young, Johannes Reisert, Yixian Zheng () and Haiqing Zhao ()
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Crystal M. Gigante: The Johns Hopkins University
Michele Dibattista: Monell Chemical Senses Center
Frederick N. Dong: The Johns Hopkins University
Xiaobin Zheng: Carnegie Institution for Science
Sibiao Yue: Carnegie Institution for Science
Stephen G. Young: University of California
Johannes Reisert: Monell Chemical Senses Center
Yixian Zheng: Carnegie Institution for Science
Haiqing Zhao: The Johns Hopkins University

Nature Communications, 2017, vol. 8, issue 1, 1-13

Abstract: Abstract B-type lamins are major constituents of the nuclear lamina in all metazoan cells, yet have specific roles in the development of certain cell types. Although they are speculated to regulate gene expression in developmental contexts, a direct link between B-type lamins and developmental gene expression in an in vivo system is currently lacking. Here, we identify lamin B1 as a key regulator of gene expression required for the formation of functional olfactory sensory neurons. By using targeted knockout in olfactory epithelial stem cells in adult mice, we show that lamin B1 deficient neurons exhibit attenuated response to odour stimulation. This deficit can be explained by decreased expression of genes involved in mature neuron function, along with increased expression of genes atypical of the olfactory lineage. These results support that the broadly expressed lamin B1 regulates expression of a subset of genes involved in the differentiation of a specific cell type.

Date: 2017
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DOI: 10.1038/ncomms15098

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