Nanodiamond-enhanced MRI via in situ hyperpolarization

David E. J. Waddington, Mathieu Sarracanie, Huiliang Zhang, Najat Salameh, David R. Glenn, Ewa Rej, Torsten Gaebel, Thomas Boele, Ronald L. Walsworth, David J. Reilly and Matthew S. Rosen ()
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David E. J. Waddington: A.A. Martinos Center for Biomedical Imaging
Mathieu Sarracanie: A.A. Martinos Center for Biomedical Imaging
Huiliang Zhang: Harvard University
Najat Salameh: A.A. Martinos Center for Biomedical Imaging
David R. Glenn: Harvard University
Ewa Rej: ARC Centre of Excellence for Engineered Quantum Systems, School of Physics, University of Sydney
Torsten Gaebel: ARC Centre of Excellence for Engineered Quantum Systems, School of Physics, University of Sydney
Thomas Boele: ARC Centre of Excellence for Engineered Quantum Systems, School of Physics, University of Sydney
Ronald L. Walsworth: Harvard University
David J. Reilly: ARC Centre of Excellence for Engineered Quantum Systems, School of Physics, University of Sydney
Matthew S. Rosen: A.A. Martinos Center for Biomedical Imaging

Nature Communications, 2017, vol. 8, issue 1, 1-8

Abstract: Abstract Nanodiamonds are of interest as nontoxic substrates for targeted drug delivery and as highly biostable fluorescent markers for cellular tracking. Beyond optical techniques, however, options for noninvasive imaging of nanodiamonds in vivo are severely limited. Here, we demonstrate that the Overhauser effect, a proton–electron polarization transfer technique, can enable high-contrast magnetic resonance imaging (MRI) of nanodiamonds in water at room temperature and ultra-low magnetic field. The technique transfers spin polarization from paramagnetic impurities at nanodiamond surfaces to 1H spins in the surrounding water solution, creating MRI contrast on-demand. We examine the conditions required for maximum enhancement as well as the ultimate sensitivity of the technique. The ability to perform continuous in situ hyperpolarization via the Overhauser mechanism, in combination with the excellent in vivo stability of nanodiamond, raises the possibility of performing noninvasive in vivo tracking of nanodiamond over indefinitely long periods of time.

Date: 2017
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DOI: 10.1038/ncomms15118

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