Antibody-powered nucleic acid release using a DNA-based nanomachine

Simona Ranallo, Carl Prévost-Tremblay, Andrea Idili, Alexis Vallée-Bélisle and Francesco Ricci ()
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Simona Ranallo: University of Rome, Tor Vergata, Via della Ricerca Scientifica
Carl Prévost-Tremblay: Laboratory of Biosensors and Nanomachines, Départment de Biochimie et Médecine Moléculaire, Université de Montréal
Andrea Idili: University of Rome, Tor Vergata, Via della Ricerca Scientifica
Alexis Vallée-Bélisle: Laboratory of Biosensors and Nanomachines, Départment de Biochimie et Médecine Moléculaire, Université de Montréal
Francesco Ricci: University of Rome, Tor Vergata, Via della Ricerca Scientifica

Nature Communications, 2017, vol. 8, issue 1, 1-9

Abstract: Abstract A wide range of molecular devices with nanoscale dimensions have been recently designed to perform a variety of functions in response to specific molecular inputs. Only limited examples, however, utilize antibodies as regulatory inputs. In response to this, here we report the rational design of a modular DNA-based nanomachine that can reversibly load and release a molecular cargo on binding to a specific antibody. We show here that, by using three different antigens (including one relevant to HIV), it is possible to design different DNA nanomachines regulated by their targeting antibody in a rapid, versatile and highly specific manner. The antibody-powered DNA nanomachines we have developed here may thus be useful in applications like controlled drug-release, point-of-care diagnostics and in vivo imaging.

Date: 2017
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DOI: 10.1038/ncomms15150

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