Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen

Celia Miguel-Blanco, Irene Molina, Ana I. Bardera, Beatriz Díaz, Laura de las Heras, Sonia Lozano, Carolina González, Janneth Rodrigues, Michael J. Delves, Andrea Ruecker, Gonzalo Colmenarejo, Sara Viera, María S. Martínez-Martínez, Esther Fernández, Jake Baum, Robert E. Sinden and Esperanza Herreros ()
Additional contact information
Celia Miguel-Blanco: Diseases of the Developing World (DDW), GlaxoSmithKline
Irene Molina: Diseases of the Developing World (DDW), GlaxoSmithKline
Ana I. Bardera: Molecular Discovery Research (MDR), GlaxoSmithKline
Beatriz Díaz: Diseases of the Developing World (DDW), GlaxoSmithKline
Laura de las Heras: Diseases of the Developing World (DDW), GlaxoSmithKline
Sonia Lozano: Diseases of the Developing World (DDW), GlaxoSmithKline
Carolina González: Diseases of the Developing World (DDW), GlaxoSmithKline
Janneth Rodrigues: Diseases of the Developing World (DDW), GlaxoSmithKline
Michael J. Delves: Imperial College of London
Andrea Ruecker: Imperial College of London
Gonzalo Colmenarejo: Molecular Discovery Research (MDR), GlaxoSmithKline
Sara Viera: Diseases of the Developing World (DDW), GlaxoSmithKline
María S. Martínez-Martínez: Diseases of the Developing World (DDW), GlaxoSmithKline
Esther Fernández: Diseases of the Developing World (DDW), GlaxoSmithKline
Jake Baum: Imperial College of London
Robert E. Sinden: Imperial College of London
Esperanza Herreros: Diseases of the Developing World (DDW), GlaxoSmithKline

Nature Communications, 2017, vol. 8, issue 1, 1-10

Abstract: Abstract Plasmodium falciparum stage V gametocytes are responsible for parasite transmission, and drugs targeting this stage are needed to support malaria elimination. We here screen the Tres Cantos Antimalarial Set (TCAMS) using the previously developed P. falciparum female gametocyte activation assay (Pf FGAA), which assesses stage V female gametocyte viability and functionality using Pfs25 expression. We identify over 400 compounds with activities

Date: 2017
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms15160 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15160

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms15160

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().