A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory

Virginie Freytag (), Tania Carrillo-Roa, Annette Milnik, Philipp G. Sämann, Vanja Vukojevic, David Coynel, Philippe Demougin, Tobias Egli, Leo Gschwind, Frank Jessen, Eva Loos, Wolfgang Maier, Steffi G. Riedel-Heller, Martin Scherer, Christian Vogler, Michael Wagner, Elisabeth B. Binder, Dominique J. -F. de Quervain and Andreas Papassotiropoulos ()
Additional contact information
Virginie Freytag: University of Basel
Tania Carrillo-Roa: Max Planck Institute of Psychiatry
Annette Milnik: University of Basel
Philipp G. Sämann: Max Planck Institute of Psychiatry
Vanja Vukojevic: University of Basel
David Coynel: Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
Philippe Demougin: University of Basel
Tobias Egli: University of Basel
Leo Gschwind: Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
Frank Jessen: German Center for Neurodegenerative Diseases (DZNE)
Eva Loos: Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
Wolfgang Maier: German Center for Neurodegenerative Diseases (DZNE)
Steffi G. Riedel-Heller: Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig
Martin Scherer: Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf
Christian Vogler: University of Basel
Michael Wagner: German Center for Neurodegenerative Diseases (DZNE)
Elisabeth B. Binder: Max Planck Institute of Psychiatry
Dominique J. -F. de Quervain: Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
Andreas Papassotiropoulos: University of Basel

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract Increasing age is tightly linked to decreased thickness of the human neocortex. The biological mechanisms that mediate this effect are hitherto unknown. The DNA methylome, as part of the epigenome, contributes significantly to age-related phenotypic changes. Here, we identify an epigenetic signature that is associated with cortical thickness (P=3.86 × 10−8) and memory performance in 533 healthy young adults. The epigenetic effect on cortical thickness was replicated in a sample comprising 596 participants with major depressive disorder and healthy controls. The epigenetic signature mediates partially the effect of age on cortical thickness (P

Date: 2017
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DOI: 10.1038/ncomms15193

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