Induction of resident memory T cells enhances the efficacy of cancer vaccine

Mevyn Nizard, Hélène Roussel, Mariana O. Diniz, Soumaya Karaki, Thi Tran, Thibault Voron, Estelle Dransart, Federico Sandoval, Marc Riquet, Bastien Rance, Elie Marcheteau, Elizabeth Fabre, Marion Mandavit, Magali Terme, Charlotte Blanc, Jean-Baptiste Escudie, Laure Gibault, Françoise Le Pimpec Barthes, Clemence Granier, Luis C. S. Ferreira, Cecile Badoual, Ludger Johannes and Eric Tartour ()
Additional contact information
Mevyn Nizard: INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
Hélène Roussel: INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
Mariana O. Diniz: INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
Soumaya Karaki: INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
Thi Tran: INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
Thibault Voron: INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
Estelle Dransart: Institut Curie, PSL Research University, Chemical Biology of Membranes and Therapeutic Delivery Unit
Federico Sandoval: INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
Marc Riquet: Hopital Europeen Georges Pompidou, Chrirurgie Thoracique Générale, Oncologique et Transplantation
Bastien Rance: Hopital Européen Georges Pompidou
Elie Marcheteau: INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
Elizabeth Fabre: Departement of Medical Oncology, Hopital Européen Georges Pompidou
Marion Mandavit: INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
Magali Terme: INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
Charlotte Blanc: INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
Jean-Baptiste Escudie: Hopital Européen Georges Pompidou
Laure Gibault: Hopital Européen Georges Pompidou
Françoise Le Pimpec Barthes: Hopital Europeen Georges Pompidou, Chrirurgie Thoracique Générale, Oncologique et Transplantation
Clemence Granier: INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
Luis C. S. Ferreira: Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes
Cecile Badoual: INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité
Ludger Johannes: Institut Curie, PSL Research University, Chemical Biology of Membranes and Therapeutic Delivery Unit
Eric Tartour: INSERM U970, Université Paris Descartes, Sorbonne Paris-Cité

Nature Communications, 2017, vol. 8, issue 1, 1-11

Abstract: Abstract Tissue-resident memory T cells (Trm) represent a new subset of long-lived memory T cells that remain in tissue and do not recirculate. Although they are considered as early immune effectors in infectious diseases, their role in cancer immunosurveillance remains unknown. In a preclinical model of head and neck cancer, we show that intranasal vaccination with a mucosal vector, the B subunit of Shiga toxin, induces local Trm and inhibits tumour growth. As Trm do not recirculate, we demonstrate their crucial role in the efficacy of cancer vaccine with parabiosis experiments. Blockade of TFGβ decreases the induction of Trm after mucosal vaccine immunization, resulting in the lower efficacy of cancer vaccine. In order to extrapolate this role of Trm in humans, we show that the number of Trm correlates with a better overall survival in lung cancer in multivariate analysis. The induction of Trm may represent a new surrogate biomarker for the efficacy of cancer vaccine. This study also argues for the development of vaccine strategies designed to elicit them.

Date: 2017
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DOI: 10.1038/ncomms15221

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