Sara phosphorylation state controls the dispatch of endosomes from the central spindle during asymmetric division

Sylvain Loubéry, Alicia Daeden, Carole Seum, Laurent Holtzer, Ana Moraleda, Nicolas Damond, Emmanuel Derivery, Thomas Schmidt and Marcos Gonzalez-Gaitan ()
Additional contact information
Sylvain Loubéry: University of Geneva
Alicia Daeden: University of Geneva
Carole Seum: University of Geneva
Laurent Holtzer: University of Geneva
Ana Moraleda: University of Geneva
Nicolas Damond: University of Geneva
Emmanuel Derivery: University of Geneva
Thomas Schmidt: University of Geneva
Marcos Gonzalez-Gaitan: University of Geneva

Nature Communications, 2017, vol. 8, issue 1, 1-11

Abstract: Abstract During asymmetric division, fate assignation in daughter cells is mediated by the partition of determinants from the mother. In the fly sensory organ precursor cell, Notch signalling partitions into the pIIa daughter. Notch and its ligand Delta are endocytosed into Sara endosomes in the mother cell and they are first targeted to the central spindle, where they get distributed asymmetrically to finally be dispatched to pIIa. While the processes of endosomal targeting and asymmetry are starting to be understood, the machineries implicated in the final dispatch to pIIa are unknown. We show that Sara binds the PP1c phosphatase and its regulator Sds22. Sara phosphorylation on three specific sites functions as a switch for the dispatch: if not phosphorylated, endosomes are targeted to the spindle and upon phosphorylation of Sara, endosomes detach from the spindle during pIIa targeting.

Date: 2017
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms15285 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15285

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms15285

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().