TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice

Maria Cristina Marrone, Annunziato Morabito, Michela Giustizieri, Valerio Chiurchiù, Alessandro Leuti, Marzia Mattioli, Sara Marinelli, Loredana Riganti, Marta Lombardi, Emanuele Murana, Antonio Totaro, Daniele Piomelli, Davide Ragozzino, Sergio Oddi, Mauro Maccarrone, Claudia Verderio and Silvia Marinelli ()
Additional contact information
Maria Cristina Marrone: European Brain Research Institute-Fondazione Rita Levi Montalcini
Annunziato Morabito: European Brain Research Institute-Fondazione Rita Levi Montalcini
Michela Giustizieri: European Brain Research Institute-Fondazione Rita Levi Montalcini
Valerio Chiurchiù: IRCCS Fondazione Santa Lucia
Alessandro Leuti: IRCCS Fondazione Santa Lucia
Marzia Mattioli: European Brain Research Institute-Fondazione Rita Levi Montalcini
Sara Marinelli: European Brain Research Institute-Fondazione Rita Levi Montalcini
Loredana Riganti: CNR Institute of Neuroscience, via Vanvitelli 32
Marta Lombardi: IRCCS Humanitas, via Manzoni 56
Emanuele Murana: Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome
Antonio Totaro: IRCCS Fondazione Santa Lucia
Daniele Piomelli: Drug Discovery and Development, Fondazione Istituto Italiano di Tecnologia
Davide Ragozzino: Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome
Sergio Oddi: IRCCS Fondazione Santa Lucia
Mauro Maccarrone: IRCCS Fondazione Santa Lucia
Claudia Verderio: CNR-National Research Council, Institute of Cell Biology and Neurobiology
Silvia Marinelli: European Brain Research Institute-Fondazione Rita Levi Montalcini

Nature Communications, 2017, vol. 8, issue 1, 1-18

Abstract: Abstract The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a key component of pain and inflammation. A large amount of evidence shows that TRPV1 is also functional in the brain although its role is still debated. Here we report that TRPV1 is highly expressed in microglial cells rather than neurons of the anterior cingulate cortex and other brain areas. We found that stimulation of microglial TRPV1 controls cortical microglia activation per se and indirectly enhances glutamatergic transmission in neurons by promoting extracellular microglial microvesicles shedding. Conversely, in the cortex of mice suffering from neuropathic pain, TRPV1 is also present in neurons affecting their intrinsic electrical properties and synaptic strength. Altogether, these findings identify brain TRPV1 as potential detector of harmful stimuli and a key player of microglia to neuron communication.

Date: 2017
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DOI: 10.1038/ncomms15292

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