Engineered clearing agents for the selective depletion of antigen-specific antibodies

Siva Charan Devanaboyina, Priyanka Khare, Dilip K. Challa, Raimund J. Ober () and E. Sally Ward ()
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Siva Charan Devanaboyina: Texas A&M University Health Science Center
Priyanka Khare: Texas A&M University Health Science Center
Dilip K. Challa: Texas A&M University Health Science Center
Raimund J. Ober: Texas A&M University Health Science Center
E. Sally Ward: Texas A&M University Health Science Center

Nature Communications, 2017, vol. 8, issue 1, 1-6

Abstract: Abstract Here we have designed a novel class of engineered antibody-based reagents (‘Seldegs’) that induce the selective degradation of antigen-specific antibodies. We demonstrate the rapid and specific clearance of antibodies recognizing the autoantigen, myelin oligodendrocyte glycoprotein and tumour target, HER2. Seldegs have considerable potential in multiple areas, including the treatment of antibody-mediated autoimmunity and diagnostic imaging.

Date: 2017
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DOI: 10.1038/ncomms15314

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