Underwater Leidenfrost nanochemistry for creation of size-tailored zinc peroxide cancer nanotherapeutics

Mady Elbahri (), Ramzy Abdelaziz, Duygu Disci-Zayed, Shahin Homaeigohar, Justyna Sosna, Dieter Adam, Lorenz Kienle, Torben Dankwort and Moheb Abdelaziz
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Mady Elbahri: Nanochemistry and Nanoengineering, School of Chemical Engineering, Aalto University
Ramzy Abdelaziz: Nanochemistry and Nanoengineering, School of Chemical Engineering, Aalto University
Duygu Disci-Zayed: Nanochemistry and Nanoengineering, Institute for Materials Science, Faculty of Engineering, Kiel University
Shahin Homaeigohar: Nanochemistry and Nanoengineering, School of Chemical Engineering, Aalto University
Justyna Sosna: Institute of Immunology, Kiel University
Dieter Adam: Institute of Immunology, Kiel University
Lorenz Kienle: Synthesis and Real Structure, Institute for Materials Science, Faculty of Engineering, Kiel University
Torben Dankwort: Synthesis and Real Structure, Institute for Materials Science, Faculty of Engineering, Kiel University
Moheb Abdelaziz: Nanochemistry and Nanoengineering, School of Chemical Engineering, Aalto University

Nature Communications, 2017, vol. 8, issue 1, 1-10

Abstract: Abstract The dynamic underwater chemistry seen in nature is inspiring for the next generation of eco-friendly nanochemistry. In this context, green synthesis of size-tailored nanoparticles in a facile and scalable manner via a dynamic process is an interesting challenge. Simulating the volcano-induced dynamic chemistry of the deep ocean, here we demonstrate the Leidenfrost dynamic chemistry occurring in an underwater overheated confined zone as a new tool for customized creation of nanoclusters of zinc peroxide. The hydrodynamic nature of the phenomenon ensures eruption of the nanoclusters towards a much colder region, giving rise to growth of monodisperse, size-tailored nanoclusters. Such nanoparticles are investigated in terms of their cytotoxicity on suspension and adherent cells to prove their applicability as cancer nanotherapeutics. Our research can pave the way for employment of the dynamic green nanochemistry in facile, scalable fabrication of size-tailored nanoparticles for biomedical applications.

Date: 2017
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DOI: 10.1038/ncomms15319

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