ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics

Yanlei Ma, Jiping Yue, Yao Zhang, Chenzhang Shi, Matt Odenwald, Wenguang G. Liang, Qing Wei, Ajay Goel, Xuewen Gou, Jamie Zhang, Shao-Yu Chen, Wei-Jen Tang, Jerrold R. Turner, Feng Yang (), Hong Liang (), Huanlong Qin () and Xiaoyang Wu ()
Additional contact information
Yanlei Ma: Shanghai Tenth People’s Hospital Affiliated with Tongji University
Jiping Yue: The University of Chicago
Yao Zhang: Fudan University Shanghai Cancer Center
Chenzhang Shi: Shanghai Tenth People’s Hospital Affiliated with Tongji University
Matt Odenwald: Pritzker School of Medicine, University of Chicago
Wenguang G. Liang: The University of Chicago
Qing Wei: Shanghai Tenth People’s Hospital Affiliated with Tongji University
Ajay Goel: Center for Gastrointestinal Research, Center for Epigenetics, Cancer Prevention and Cancer Genomics, Baylor Scott & White Research Institute and Charles A. Sammons Cancer Center
Xuewen Gou: The University of Chicago
Jamie Zhang: The University of Chicago
Shao-Yu Chen: University of Louisville Health Science Center
Wei-Jen Tang: The University of Chicago
Jerrold R. Turner: Brigham and Women’s Hospital, Harvard Medical School
Feng Yang: State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Science and Technology of China, Guanxi Normal University
Hong Liang: State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Science and Technology of China, Guanxi Normal University
Huanlong Qin: Shanghai Tenth People’s Hospital Affiliated with Tongji University
Xiaoyang Wu: The University of Chicago

Nature Communications, 2017, vol. 8, issue 1, 1-16

Abstract: Abstract In the intestinal epithelium, the aberrant regulation of cell/cell junctions leads to intestinal barrier defects, which may promote the onset and enhance the severity of inflammatory bowel disease (IBD). However, it remains unclear how the coordinated behaviour of cytoskeletal network may contribute to cell junctional dynamics. In this report, we identified ACF7, a crosslinker of microtubules and F-actin, as an essential player in this process. Loss of ACF7 leads to aberrant microtubule organization, tight junction stabilization and impaired wound closure in vitro. With the mouse genetics approach, we show that ablation of ACF7 inhibits intestinal wound healing and greatly increases susceptibility to experimental colitis in mice. ACF7 level is also correlated with development and progression of ulcerative colitis (UC) in human patients. Together, our results reveal an important molecular mechanism whereby coordinated cytoskeletal dynamics contributes to cell adhesion regulation during intestinal wound repair and the development of IBD.

Date: 2017
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DOI: 10.1038/ncomms15375

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