Engaging and disengaging recurrent inhibition coincides with sensing and unsensing of a sensory stimulus

Debajit Saha, Wensheng Sun, Chao Li, Srinath Nizampatnam, William Padovano, Zhengdao Chen, Alex Chen, Ege Altan, Ray Lo, Dennis L. Barbour and Baranidharan Raman ()
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Debajit Saha: Washington University in St. Louis
Wensheng Sun: Washington University in St. Louis
Chao Li: Washington University in St. Louis
Srinath Nizampatnam: Washington University in St. Louis
William Padovano: Washington University in St. Louis
Zhengdao Chen: Washington University in St. Louis
Alex Chen: Washington University in St. Louis
Ege Altan: Washington University in St. Louis
Ray Lo: Washington University in St. Louis
Dennis L. Barbour: Washington University in St. Louis
Baranidharan Raman: Washington University in St. Louis

Nature Communications, 2017, vol. 8, issue 1, 1-19

Abstract: Abstract Even simple sensory stimuli evoke neural responses that are dynamic and complex. Are the temporally patterned neural activities important for controlling the behavioral output? Here, we investigated this issue. Our results reveal that in the insect antennal lobe, due to circuit interactions, distinct neural ensembles are activated during and immediately following the termination of every odorant. Such non-overlapping response patterns are not observed even when the stimulus intensity or identities were changed. In addition, we find that ON and OFF ensemble neural activities differ in their ability to recruit recurrent inhibition, entrain field-potential oscillations and more importantly in their relevance to behaviour (initiate versus reset conditioned responses). Notably, we find that a strikingly similar strategy is also used for encoding sound onsets and offsets in the marmoset auditory cortex. In sum, our results suggest a general approach where recurrent inhibition is associated with stimulus ‘recognition’ and ‘derecognition’.

Date: 2017
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DOI: 10.1038/ncomms15413

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