Dynamic diversity of synthetic supramolecular polymers in water as revealed by hydrogen/deuterium exchange

Xianwen Lou, René P. M. Lafleur, Christianus M. A. Leenders, Sandra M. C. Schoenmakers, Nicholas M. Matsumoto, Matthew B. Baker, Joost L. J. van Dongen, Anja R. A. Palmans () and E W Meijer ()
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Xianwen Lou: Institute for Complex Molecular Systems, Eindhoven University of Technology
René P. M. Lafleur: Institute for Complex Molecular Systems, Eindhoven University of Technology
Christianus M. A. Leenders: Institute for Complex Molecular Systems, Eindhoven University of Technology
Sandra M. C. Schoenmakers: Institute for Complex Molecular Systems, Eindhoven University of Technology
Nicholas M. Matsumoto: Institute for Complex Molecular Systems, Eindhoven University of Technology
Matthew B. Baker: Institute for Complex Molecular Systems, Eindhoven University of Technology
Joost L. J. van Dongen: Institute for Complex Molecular Systems, Eindhoven University of Technology
Anja R. A. Palmans: Institute for Complex Molecular Systems, Eindhoven University of Technology
E W Meijer: Institute for Complex Molecular Systems, Eindhoven University of Technology

Nature Communications, 2017, vol. 8, issue 1, 1-8

Abstract: Abstract Numerous self-assembling molecules have been synthesized aiming at mimicking both the structural and dynamic properties found in living systems. Here we show the application of hydrogen/deuterium exchange (HDX) mass spectrometry (MS) to unravel the nanoscale organization and the structural dynamics of synthetic supramolecular polymers in water. We select benzene-1,3,5-tricarboxamide (BTA) derivatives that self-assemble in H2O to illustrate the strength of this technique for supramolecular polymers. The BTA structure has six exchangeable hydrogen atoms and we follow their exchange as a function of time after diluting the H2O solution with a 100-fold excess of D2O. The kinetic H/D exchange profiles reveal that these supramolecular polymers in water are dynamically diverse; a notion that has previously not been observed using other techniques. In addition, we report that small changes in the molecular structure can be used to control the dynamics of synthetic supramolecular polymers in water.

Date: 2017
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DOI: 10.1038/ncomms15420

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