Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing

Rutger C. C. Hengeveld, Martijn J. M. Vromans, Mathijs Vleugel, Michael A. Hadders and Susanne M. A. Lens ()
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Rutger C. C. Hengeveld: Center for Molecular Medicine, University Medical Center Utrecht
Martijn J. M. Vromans: Center for Molecular Medicine, University Medical Center Utrecht
Mathijs Vleugel: Center for Molecular Medicine, University Medical Center Utrecht
Michael A. Hadders: Center for Molecular Medicine, University Medical Center Utrecht
Susanne M. A. Lens: Center for Molecular Medicine, University Medical Center Utrecht

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract Faithful chromosome segregation during mitosis requires that the kinetochores of all sister chromatids become stably connected to microtubules derived from opposite spindle poles. How stable chromosome bi-orientation is accomplished and coordinated with anaphase onset remains incompletely understood. Here we show that stable chromosome bi-orientation requires inner centromere localization of the non-enzymatic subunits of the chromosomal passenger complex (CPC) to maintain centromeric cohesion. Precise inner centromere localization of the CPC appears less relevant for Aurora B-dependent resolution of erroneous kinetochore–microtubule (KT–MT) attachments and for the stabilization of bi-oriented KT–MT attachments once sister chromatid cohesion is preserved via knock-down of WAPL. However, Aurora B inner centromere localization is essential for mitotic checkpoint silencing to allow spatial separation from its kinetochore substrate KNL1. Our data infer that the CPC is localized at the inner centromere to sustain centromere cohesion on bi-oriented chromosomes and to coordinate mitotic checkpoint silencing with chromosome bi-orientation.

Date: 2017
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DOI: 10.1038/ncomms15542

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