Exploring chemoselective S-to-N acyl transfer reactions in synthesis and chemical biology

Helen M. Burke, Lauren McSweeney and Eoin M. Scanlan ()
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Helen M. Burke: School of Chemistry, Trinity College Dublin
Lauren McSweeney: School of Chemistry, Trinity College Dublin
Eoin M. Scanlan: School of Chemistry, Trinity College Dublin

Nature Communications, 2017, vol. 8, issue 1, 1-16

Abstract: S-to-N acyl transfer is a high-yielding chemoselective process for amide bond formation. It is widely utilized by chemists for synthetic applications, including peptide and protein synthesis, chemical modification of proteins, protein-protein ligation and the development of probes and molecular machines. Recent advances in our understanding of S-to-N acyl transfer processes in biology and innovations in methodology for thioester formation and desulfurization, together with an extension of the size of cyclic transition states, have expanded the boundaries of this process well beyond peptide ligation. As the field develops, this chemistry will play a central role in our molecular understanding of Biology.

Date: 2017
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DOI: 10.1038/ncomms15655

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