Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus

Petraleigh Pantoja, Erick X. Pérez-Guzmán, Idia V. Rodríguez, Laura J. White, Olga González, Crisanta Serrano, Luis Giavedoni, Vida Hodara, Lorna Cruz, Teresa Arana, Melween I. Martínez, Mariah A. Hassert, James D. Brien, Amelia K. Pinto, Aravinda de Silva and Carlos A. Sariol ()
Additional contact information
Petraleigh Pantoja: Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus
Erick X. Pérez-Guzmán: University of Puerto Rico-Medical Sciences Campus
Idia V. Rodríguez: Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus
Laura J. White: University of North Carolina-Chapel Hill
Olga González: Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus
Crisanta Serrano: University of Puerto Rico-Medical Sciences Campus
Luis Giavedoni: Texas Biomedical Research Institute
Vida Hodara: Texas Biomedical Research Institute
Lorna Cruz: Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus
Teresa Arana: University of Puerto Rico-Medical Sciences Campus
Melween I. Martínez: Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus
Mariah A. Hassert: Saint Louis University School of Medicine
James D. Brien: Saint Louis University School of Medicine
Amelia K. Pinto: Saint Louis University School of Medicine
Aravinda de Silva: University of North Carolina-Chapel Hill
Carlos A. Sariol: Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus

Nature Communications, 2017, vol. 8, issue 1, 1-13

Abstract: Abstract Zika virus (ZIKV) is a re-emerging virus that has recently spread into dengue virus (DENV) endemic regions and cross-reactive antibodies (Abs) could potentially affect ZIKV pathogenesis. Using DENV-immune serum, it has been shown in vitro that antibody-dependent enhancement (ADE) of ZIKV infection can occur. Here we study the effects of pre-existing DENV immunity on ZIKV infection in vivo. We infect two cohorts of rhesus macaques with ZIKV; one cohort has been exposed to DENV 2.8 years earlier and a second control cohort is naïve to flaviviral infection. Our results, while confirming ADE in vitro, suggest that pre-existing DENV immunity does not result in more severe ZIKV disease. Rather our results show a reduction in the number of days of ZIKV viremia compared to naïve macaques and that the previous exposure to DENV may result in modulation of the immune response without resulting in enhancement of ZIKV pathogenesis.

Date: 2017
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DOI: 10.1038/ncomms15674

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