Genome-wide association study identifies multiple risk loci for renal cell carcinoma

Ghislaine Scelo, Mark P. Purdue, Kevin M. Brown, Mattias Johansson, Zhaoming Wang, Jeanette E. Eckel-Passow, Yuanqing Ye, Jonathan N. Hofmann, Jiyeon Choi, Matthieu Foll, Valerie Gaborieau, Mitchell J. Machiela, Leandro M. Colli, Peng Li, Joshua N. Sampson, Behnoush Abedi-Ardekani, Celine Besse, Helene Blanche, Anne Boland, Laurie Burdette, Amelie Chabrier, Geoffroy Durand, Florence Le Calvez-Kelm, Egor Prokhortchouk, Nivonirina Robinot, Konstantin G. Skryabin, Magdalena B. Wozniak, Meredith Yeager, Gordana Basta-Jovanovic, Zoran Dzamic, Lenka Foretova, Ivana Holcatova, Vladimir Janout, Dana Mates, Anush Mukeriya, Stefan Rascu, David Zaridze, Vladimir Bencko, Cezary Cybulski, Eleonora Fabianova, Viorel Jinga, Jolanta Lissowska, Jan Lubinski, Marie Navratilova, Peter Rudnai, Neonila Szeszenia-Dabrowska, Simone Benhamou, Geraldine Cancel-Tassin, Olivier Cussenot, Laura Baglietto, Heiner Boeing, Kay-Tee Khaw, Elisabete Weiderpass, Borje Ljungberg, Raviprakash T. Sitaram, Fiona Bruinsma, Susan J. Jordan, Gianluca Severi, Ingrid Winship, Kristian Hveem, Lars J. Vatten, Tony Fletcher, Kvetoslava Koppova, Susanna C. Larsson, Alicja Wolk, Rosamonde E. Banks, Peter J. Selby, Douglas F. Easton, Paul Pharoah, Gabriella Andreotti, Laura E. Beane Freeman, Stella Koutros, Demetrius Albanes, Satu Männistö, Stephanie Weinstein, Peter E. Clark, Todd L. Edwards, Loren Lipworth, Susan M. Gapstur, Victoria L. Stevens, Hallie Carol, Matthew L. Freedman, Mark M. Pomerantz, Eunyoung Cho, Peter Kraft, Mark A. Preston, Kathryn M. Wilson, J. Michael Gaziano, Howard D. Sesso, Amanda Black, Neal D. Freedman, Wen-Yi Huang, John G. Anema, Richard J. Kahnoski, Brian R. Lane, Sabrina L. Noyes, David Petillo, Bin Tean Teh, Ulrike Peters, Emily White, Garnet L. Anderson, Lisa Johnson, Juhua Luo, Julie Buring, I-Min Lee, Wong-Ho Chow, Lee E. Moore, Christopher Wood, Timothy Eisen, Marc Henrion, James Larkin, Poulami Barman, Bradley C. Leibovich, Toni K. Choueiri, G. Mark Lathrop, Nathaniel Rothman, Jean-Francois Deleuze, James D. McKay, Alexander S. Parker, Xifeng Wu, Richard S. Houlston, Paul Brennan () and Stephen J. Chanock ()
Additional contact information
Ghislaine Scelo: International Agency for Research on Cancer (IARC)
Mark P. Purdue: National Cancer Institute, National Institutes of Health
Kevin M. Brown: National Cancer Institute, National Institutes of Health
Mattias Johansson: International Agency for Research on Cancer (IARC)
Zhaoming Wang: St Jude Children's Research Hospital
Jeanette E. Eckel-Passow: Mayo Clinic
Yuanqing Ye: The University of Texas MD Anderson Cancer Center
Jonathan N. Hofmann: National Cancer Institute, National Institutes of Health
Jiyeon Choi: National Cancer Institute, National Institutes of Health
Matthieu Foll: International Agency for Research on Cancer (IARC)
Valerie Gaborieau: International Agency for Research on Cancer (IARC)
Mitchell J. Machiela: National Cancer Institute, National Institutes of Health
Leandro M. Colli: National Cancer Institute, National Institutes of Health
Peng Li: International Agency for Research on Cancer (IARC)
Joshua N. Sampson: National Cancer Institute, National Institutes of Health
Behnoush Abedi-Ardekani: International Agency for Research on Cancer (IARC)
Celine Besse: Centre National de Genotypage, Institut de Genomique, Commissariat à l'Energie Atomique et aux Energies Alternatives
Helene Blanche: Fondation Jean Dausset-Centre d'Etude du Polymorphisme Humain
Anne Boland: Centre National de Genotypage, Institut de Genomique, Commissariat à l'Energie Atomique et aux Energies Alternatives
Laurie Burdette: National Cancer Institute, National Institutes of Health
Amelie Chabrier: International Agency for Research on Cancer (IARC)
Geoffroy Durand: International Agency for Research on Cancer (IARC)
Florence Le Calvez-Kelm: International Agency for Research on Cancer (IARC)
Egor Prokhortchouk: Center ‘Bioengineering’ of the Russian Academy of Sciences
Nivonirina Robinot: International Agency for Research on Cancer (IARC)
Konstantin G. Skryabin: Center ‘Bioengineering’ of the Russian Academy of Sciences
Magdalena B. Wozniak: International Agency for Research on Cancer (IARC)
Meredith Yeager: National Cancer Institute, National Institutes of Health
Gordana Basta-Jovanovic: Institute of Pathology, School of Medicine, University of Belgrade
Zoran Dzamic: Clinical Center of Serbia (KCS), Clinic of Urology, University of Belgrade-Faculty of Medicine
Lenka Foretova: Masaryk Memorial Cancer Institute
Ivana Holcatova: 2nd Faculty of Medicine, Institute of Public Health and Preventive Medicine, Charles University
Vladimir Janout: Faculty of Medicine, Palacky University
Dana Mates: National Institute of Public Health
Anush Mukeriya: Russian N.N. Blokhin Cancer Research Centre
Stefan Rascu: Carol Davila University of Medicine and Pharmacy, Th. Burghele Hospital
David Zaridze: Russian N.N. Blokhin Cancer Research Centre
Vladimir Bencko: First Faculty of Medicine, Institute of Hygiene and Epidemiology, Charles University
Cezary Cybulski: International Hereditary Cancer Center, Pomeranian Medical University
Eleonora Fabianova: Regional Authority of Public Health in Banska Bystrica
Viorel Jinga: Carol Davila University of Medicine and Pharmacy, Th. Burghele Hospital
Jolanta Lissowska: The M Sklodowska-Curie Cancer Center and Institute of Oncology
Jan Lubinski: International Hereditary Cancer Center, Pomeranian Medical University
Marie Navratilova: Masaryk Memorial Cancer Institute
Peter Rudnai: National Public Health Center, National Directorate of Environmental Health
Neonila Szeszenia-Dabrowska: Institute of Occupational Medicine
Simone Benhamou: Université Paris Diderot, INSERM, Unité Variabilité Génétique et Maladies Humaines
Geraldine Cancel-Tassin: CeRePP, Tenon Hospital
Olivier Cussenot: CeRePP, Tenon Hospital
Laura Baglietto: Centre de Recherche en Épidémiologie et Santé des Populations (CESP, Inserm U1018), Université Paris-Saclay, UPS, UVSQ, Gustave Roussy
Heiner Boeing: German Institute of Human Nutrition (DIfE) Potsdam-Rehbrücke
Kay-Tee Khaw: University of Cambridge
Elisabete Weiderpass: Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway
Borje Ljungberg: Urology and Andrology, Umeå University
Raviprakash T. Sitaram: Urology and Andrology, Umeå University
Fiona Bruinsma: Cancer Epidemiology Centre, Cancer Council Victoria
Susan J. Jordan: QIMR Berghofer Medical Research Institute
Gianluca Severi: Centre de Recherche en Épidémiologie et Santé des Populations (CESP, Inserm U1018), Université Paris-Saclay, UPS, UVSQ, Gustave Roussy
Ingrid Winship: The University of Melbourne
Kristian Hveem: HUNT Research Centre, Norwegian University of Science and Technology
Lars J. Vatten: Faculty of Medicine, Norwegian University of Science and Technology
Tony Fletcher: London School of Hygiene and Tropical Medicine, University of London
Kvetoslava Koppova: Regional Authority of Public Health in Banska Bystrica
Susanna C. Larsson: Institute of Environmental Medicine, Karolinska Institutet
Alicja Wolk: Institute of Environmental Medicine, Karolinska Institutet
Rosamonde E. Banks: Leeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James's University Hospital
Peter J. Selby: Leeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James's University Hospital
Douglas F. Easton: University of Cambridge
Paul Pharoah: University of Cambridge
Gabriella Andreotti: National Cancer Institute, National Institutes of Health
Laura E. Beane Freeman: National Cancer Institute, National Institutes of Health
Stella Koutros: National Cancer Institute, National Institutes of Health
Demetrius Albanes: National Cancer Institute, National Institutes of Health
Satu Männistö: National Institute for Health and Welfare
Stephanie Weinstein: National Cancer Institute, National Institutes of Health
Peter E. Clark: Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center
Todd L. Edwards: Vanderbilt-Ingram Cancer Center, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center
Loren Lipworth: Vanderbilt-Ingram Cancer Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center
Susan M. Gapstur: American Cancer Society
Victoria L. Stevens: American Cancer Society
Hallie Carol: Dana-Farber Cancer Institute
Matthew L. Freedman: Dana-Farber Cancer Institute
Mark M. Pomerantz: Dana-Farber Cancer Institute
Eunyoung Cho: Warren Alpert Medical School of Brown University
Peter Kraft: Harvard T.H. Chan School of Public Health
Mark A. Preston: Brigham and Women's Hospital and VA Boston
Kathryn M. Wilson: Harvard T.H. Chan School of Public Health
J. Michael Gaziano: Brigham and Women's Hospital and VA Boston
Howard D. Sesso: Harvard T.H. Chan School of Public Health
Amanda Black: National Cancer Institute, National Institutes of Health
Neal D. Freedman: National Cancer Institute, National Institutes of Health
Wen-Yi Huang: National Cancer Institute, National Institutes of Health
John G. Anema: Spectrum Health
Richard J. Kahnoski: Spectrum Health
Brian R. Lane: Spectrum Health
Sabrina L. Noyes: Van Andel Research Institute, Center for Cancer Genomics and Quantitative Biology
David Petillo: Van Andel Research Institute, Center for Cancer Genomics and Quantitative Biology
Bin Tean Teh: Van Andel Research Institute, Center for Cancer Genomics and Quantitative Biology
Ulrike Peters: Cancer Prevention Program, Fred Hutchinson Cancer Research Center
Emily White: Cancer Prevention Program, Fred Hutchinson Cancer Research Center
Garnet L. Anderson: Cancer Prevention Program, Fred Hutchinson Cancer Research Center
Lisa Johnson: Cancer Prevention Program, Fred Hutchinson Cancer Research Center
Juhua Luo: School of Public Health Indiana University Bloomington
Julie Buring: Harvard T.H. Chan School of Public Health
I-Min Lee: Harvard T.H. Chan School of Public Health
Wong-Ho Chow: The University of Texas MD Anderson Cancer Center
Lee E. Moore: National Cancer Institute, National Institutes of Health
Christopher Wood: The University of Texas M.D. Anderson Cancer Center
Timothy Eisen: Cambridge University Hospitals NHS Foundation Trust
Marc Henrion: Icahn School of Medicine at Mount Sinai
James Larkin: Medical Oncology, Royal Marsden NHS Foundation Trust
Poulami Barman: Mayo Clinic
Bradley C. Leibovich: Mayo Medical School and Mayo Clinic
Toni K. Choueiri: Dana-Farber Cancer Institute
G. Mark Lathrop: McGill University and Genome Quebec Innovation Centre
Nathaniel Rothman: National Cancer Institute, National Institutes of Health
Jean-Francois Deleuze: Centre National de Genotypage, Institut de Genomique, Commissariat à l'Energie Atomique et aux Energies Alternatives
James D. McKay: International Agency for Research on Cancer (IARC)
Alexander S. Parker: Mayo Clinic
Xifeng Wu: The University of Texas MD Anderson Cancer Center
Richard S. Houlston: The Institute of Cancer Research
Paul Brennan: International Agency for Research on Cancer (IARC)
Stephen J. Chanock: National Cancer Institute, National Institutes of Health

Nature Communications, 2017, vol. 8, issue 1, 1-9

Abstract: Abstract Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10−10), 3p22.1 (rs67311347, P=2.5 × 10−8), 3q26.2 (rs10936602, P=8.8 × 10−9), 8p21.3 (rs2241261, P=5.8 × 10−9), 10q24.33-q25.1 (rs11813268, P=3.9 × 10−8), 11q22.3 (rs74911261, P=2.1 × 10−10) and 14q24.2 (rs4903064, P=2.2 × 10−24). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.

Date: 2017
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DOI: 10.1038/ncomms15724

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