Thermal annihilation of photo-induced radicals following dynamic nuclear polarization to produce transportable frozen hyperpolarized 13C-substrates

Andrea Capozzi, Tian Cheng, Giovanni Boero, Christophe Roussel and Arnaud Comment ()
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Andrea Capozzi: Institute of Physics of Biological Systems, École Polytechnique Fédérale de Lausanne
Tian Cheng: Institute of Physics of Biological Systems, École Polytechnique Fédérale de Lausanne
Giovanni Boero: Institute of Microengineering, École Polytechnique Fédérale de Lausanne
Christophe Roussel: Section of Chemistry and Chemical Engineering, Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne
Arnaud Comment: Institute of Physics of Biological Systems, École Polytechnique Fédérale de Lausanne

Nature Communications, 2017, vol. 8, issue 1, 1-7

Abstract: Abstract Hyperpolarization via dynamic nuclear polarization (DNP) is pivotal for boosting magnetic resonance imaging (MRI) sensitivity and dissolution DNP can be used to perform in vivo real-time 13C MRI. The type of applications is however limited by the relatively fast decay time of the hyperpolarized spin state together with the constraint of having to polarize the 13C spins in a dedicated apparatus nearby but separated from the MRI magnet. We herein demonstrate that by polarizing 13C with photo-induced radicals, which can be subsequently annihilated using a thermalization process that maintains the sample temperature below its melting point, hyperpolarized 13C-substrates can be extracted from the DNP apparatus in the solid form, while maintaining the enhanced 13C polarization. The melting procedure necessary to transform the frozen solid into an injectable solution containing the hyperpolarized 13C-substrates can therefore be performed ex situ, up to several hours after extraction and storage of the polarized solid.

Date: 2017
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DOI: 10.1038/ncomms15757

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