Multifunctional nanoparticles as a tissue adhesive and an injectable marker for image-guided procedures

Kwangsoo Shin, Jin Woo Choi, Giho Ko, Seungmin Baik, Dokyoon Kim, Ok Kyu Park, Kyoungbun Lee, Hye Rim Cho, Sang Ihn Han, Soo Hong Lee, Dong Jun Lee, Nohyun Lee (), Hyo-Cheol Kim () and Taeghwan Hyeon ()
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Kwangsoo Shin: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Jin Woo Choi: Seoul National University Hospital, Seoul National University College of Medicine
Giho Ko: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Seungmin Baik: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Dokyoon Kim: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Ok Kyu Park: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Kyoungbun Lee: Seoul National University Hospital
Hye Rim Cho: Seoul National University Hospital, Seoul National University College of Medicine
Sang Ihn Han: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Soo Hong Lee: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Dong Jun Lee: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Nohyun Lee: School of Advanced Materials Engineering, Kookmin University
Hyo-Cheol Kim: Seoul National University Hospital, Seoul National University College of Medicine
Taeghwan Hyeon: Center for Nanoparticle Research, Institute for Basic Science (IBS)

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract Tissue adhesives have emerged as an alternative to sutures and staples for wound closure and reconnection of injured tissues after surgery or trauma. Owing to their convenience and effectiveness, these adhesives have received growing attention particularly in minimally invasive procedures. For safe and accurate applications, tissue adhesives should be detectable via clinical imaging modalities and be highly biocompatible for intracorporeal procedures. However, few adhesives meet all these requirements. Herein, we show that biocompatible tantalum oxide/silica core/shell nanoparticles (TSNs) exhibit not only high contrast effects for real-time imaging but also strong adhesive properties. Furthermore, the biocompatible TSNs cause much less cellular toxicity and less inflammation than a clinically used, imageable tissue adhesive (that is, a mixture of cyanoacrylate and Lipiodol). Because of their multifunctional imaging and adhesive property, the TSNs are successfully applied as a hemostatic adhesive for minimally invasive procedures and as an immobilized marker for image-guided procedures.

Date: 2017
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DOI: 10.1038/ncomms15807

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