Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes

Anand Patwardhan, Sabine Bardin, Stéphanie Miserey-Lenkei, Lionel Larue, Bruno Goud, Graça Raposo () and Cédric Delevoye ()
Additional contact information
Anand Patwardhan: Institut Curie, PSL Research University, CNRS, UMR 144, Structure and Membrane Compartments
Sabine Bardin: Institut Curie, PSL Research University, CNRS, UMR 144, Molecular Mechanisms of Intracellular Transport
Stéphanie Miserey-Lenkei: Institut Curie, PSL Research University, CNRS, UMR 144, Molecular Mechanisms of Intracellular Transport
Lionel Larue: Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes
Bruno Goud: Institut Curie, PSL Research University, CNRS, UMR 144, Molecular Mechanisms of Intracellular Transport
Graça Raposo: Institut Curie, PSL Research University, CNRS, UMR 144, Structure and Membrane Compartments
Cédric Delevoye: Institut Curie, PSL Research University, CNRS, UMR 144, Structure and Membrane Compartments

Nature Communications, 2017, vol. 8, issue 1, 1-14

Abstract: Abstract Exocytic carriers convey neo-synthesized components from the Golgi apparatus to the cell surface. While the release and anterograde movement of Golgi-derived vesicles require the small GTPase RAB6, its effector ELKS promotes the targeting and docking of secretory vesicles to particular areas of the plasma membrane. Here, we show that specialized cell types exploit and divert the secretory pathway towards lysosome related organelles. In cultured melanocytes, the secretory route relies on RAB6 and ELKS to directly transport and dock Golgi-derived carriers to melanosomes. By delivering specific cargos, such as MART-1 and TYRP2/ DCT, the RAB6/ELKS-dependent secretory pathway controls the formation and maturation of melanosomes but also pigment synthesis. In addition, pigmentation defects are observed in RAB6 KO mice. Our data together reveal for the first time that the secretory pathway can be directed towards intracellular organelles of endosomal origin to ensure their biogenesis and function.

Date: 2017
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/ncomms15835 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15835

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms15835

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().