Differential processing of thalamic information via distinct striatal interneuron circuits

Maxime Assous, Jaime Kaminer, Fulva Shah, Arpan Garg, Tibor Koós and James M. Tepper ()
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Maxime Assous: Center for Molecular and Behavioral Neuroscience, Rutgers University
Jaime Kaminer: Center for Molecular and Behavioral Neuroscience, Rutgers University
Fulva Shah: Center for Molecular and Behavioral Neuroscience, Rutgers University
Arpan Garg: Center for Molecular and Behavioral Neuroscience, Rutgers University
Tibor Koós: Center for Molecular and Behavioral Neuroscience, Rutgers University
James M. Tepper: Center for Molecular and Behavioral Neuroscience, Rutgers University

Nature Communications, 2017, vol. 8, issue 1, 1-14

Abstract: Abstract Recent discoveries of striatal GABAergic interneurons require a new conceptualization of the organization of intrastriatal circuitry and their cortical and thalamic inputs. We investigated thalamic inputs to the two populations of striatal neuropeptide Y (NPY) interneurons, plateau low threshold spike (PLTS) and NPY-neurogliaform (NGF) cells. Optogenetic activation of parafascicular inputs evokes suprathreshold monosynaptic glutamatergic excitation in NGF interneurons and a disynaptic, nicotinic excitation through cholinergic interneurons. In contrast, the predominant response of PLTS interneurons is a disynaptic inhibition dependent on thalamic activation of striatal tyrosine hydroxylase interneurons (THINs). In contrast, THINs do not innervate NGF or fast spiking interneurons, showing significant specificity in THINs outputs. Chemospecific ablation of THINs impairs prepulse inhibition of the acoustic startle response suggesting an important behavioural role of this disynaptic pathway. Our findings demonstrate that the impact of the parafascicular nucleus on striatal activity and some related behaviour critically depend on synaptic interactions within interneuronal circuits.

Date: 2017
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DOI: 10.1038/ncomms15860

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