A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion

Yuwei Jiang, Daniel C. Berry (), Ayoung Jo, Wei Tang, Robert W. Arpke, Michael Kyba and Jonathan M. Graff ()
Additional contact information
Yuwei Jiang: University of Texas Southwestern Medical Center
Daniel C. Berry: University of Texas Southwestern Medical Center
Ayoung Jo: University of Texas Southwestern Medical Center
Wei Tang: University of Texas Southwestern Medical Center
Robert W. Arpke: Lillehei Heart Institute, University of Minnesota
Michael Kyba: Lillehei Heart Institute, University of Minnesota
Jonathan M. Graff: University of Texas Southwestern Medical Center

Nature Communications, 2017, vol. 8, issue 1, 1-16

Abstract: Abstract Adipose progenitor cells (APCs) reside in a vascular niche, located within the perivascular compartment of adipose tissue blood vessels. Yet, the signals and mechanisms that govern adipose vascular niche formation and APC niche interaction are unknown. Here we show that the assembly and maintenance of the adipose vascular niche is controlled by PPARγ acting within APCs. PPARγ triggers a molecular hierarchy that induces vascular sprouting, APC vessel niche affinity and APC vessel occupancy. Mechanistically, PPARγ transcriptionally activates PDGFRβ and VEGF. APC expression and activation of PDGFRβ promotes the recruitment and retention of APCs to the niche. Pharmacologically, targeting PDGFRβ disrupts APC niche contact thus blocking adipose tissue expansion. Moreover, enhanced APC expression of VEGF stimulates endothelial cell proliferation and expands the adipose niche. Consequently, APC niche communication and retention are boosted by VEGF thereby impairing adipogenesis. Our data indicate that APCs direct adipose tissue niche expansion via a PPARγ-initiated PDGFRβ and VEGF transcriptional axis.

Date: 2017
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/ncomms15926 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15926

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms15926

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().