Nrp2 is sufficient to instruct circuit formation of mitral-cells to mediate odour-induced attractive social responses

Kasumi Inokuchi, Fumiaki Imamura, Haruki Takeuchi, Ryang Kim, Hiroyuki Okuno, Hirofumi Nishizumi, Haruhiko Bito, Takefumi Kikusui and Hitoshi Sakano ()
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Kasumi Inokuchi: School of Medical Science, University of Fukui
Fumiaki Imamura: Pennsylvania State University College of Medicine
Haruki Takeuchi: School of Medical Science, University of Fukui
Ryang Kim: Graduate School of Medicine, The University of Tokyo
Hiroyuki Okuno: Graduate School of Medicine, The University of Tokyo
Hirofumi Nishizumi: School of Medical Science, University of Fukui
Haruhiko Bito: Graduate School of Medicine, The University of Tokyo
Takefumi Kikusui: School of Veterinary Medicine, Azabu University
Hitoshi Sakano: School of Medical Science, University of Fukui

Nature Communications, 2017, vol. 8, issue 1, 1-13

Abstract: Abstract Odour information induces various innate responses that are critical to the survival of the individual and for the species. An axon guidance molecule, Neuropilin 2 (Nrp2), is known to mediate targeting of olfactory sensory neurons (primary neurons), to the posteroventral main olfactory bulb (PV MOB) in mice. Here we report that Nrp2-positive (Nrp2+) mitral cells (MCs, second-order neurons) play crucial roles in transmitting attractive social signals from the PV MOB to the anterior part of medial amygdala (MeA). Semaphorin 3F, a repulsive ligand to Nrp2, regulates both migration of Nrp2+ MCs to the PV MOB and their axonal projection to the anterior MeA. In the MC-specific Nrp2 knockout mice, circuit formation of Nrp2+ MCs and odour-induced attractive social responses are impaired. In utero, electroporation demonstrates that activation of the Nrp2 gene in MCs is sufficient to instruct their circuit formation from the PV MOB to the anterior MeA.

Date: 2017
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DOI: 10.1038/ncomms15977

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