Regulation of Drosophila hematopoietic sites by Activin-β from active sensory neurons

Kalpana Makhijani, Brandy Alexander, Deepti Rao, Sophia Petraki, Leire Herboso, Katelyn Kukar, Itrat Batool, Stephanie Wachner, Katrina S. Gold, Corinna Wong, Michael B. O’Connor and Katja Brückner ()
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Kalpana Makhijani: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco
Brandy Alexander: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco
Deepti Rao: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco
Sophia Petraki: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco
Leire Herboso: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco
Katelyn Kukar: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco
Itrat Batool: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco
Stephanie Wachner: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco
Katrina S. Gold: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco
Corinna Wong: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco
Michael B. O’Connor: Cell Biology and Development, University of Minnesota
Katja Brückner: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract An outstanding question in animal development, tissue homeostasis and disease is how cell populations adapt to sensory inputs. During Drosophila larval development, hematopoietic sites are in direct contact with sensory neuron clusters of the peripheral nervous system (PNS), and blood cells (hemocytes) require the PNS for their survival and recruitment to these microenvironments, known as Hematopoietic Pockets. Here we report that Activin-β, a TGF-β family ligand, is expressed by sensory neurons of the PNS and regulates the proliferation and adhesion of hemocytes. These hemocyte responses depend on PNS activity, as shown by agonist treatment and transient silencing of sensory neurons. Activin-β has a key role in this regulation, which is apparent from reporter expression and mutant analyses. This mechanism of local sensory neurons controlling blood cell adaptation invites evolutionary parallels with vertebrate hematopoietic progenitors and the independent myeloid system of tissue macrophages, whose regulation by local microenvironments remain undefined.

Date: 2017
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DOI: 10.1038/ncomms15990

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