Immobility responses are induced by photoactivation of single glomerular species responsive to fox odour TMT

Harumi Saito, Hirofumi Nishizumi, Satoshi Suzuki, Hideyuki Matsumoto, Nao Ieki, Takaya Abe, Hiroshi Kiyonari, Masahiko Morita, Hideo Yokota, Nozomi Hirayama, Takahiro Yamazaki, Takefumi Kikusui, Kensaku Mori and Hitoshi Sakano ()
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Harumi Saito: Faculty of Medical Sciences, University of Fukui
Hirofumi Nishizumi: Faculty of Medical Sciences, University of Fukui
Satoshi Suzuki: Graduate School of Science, The University of Tokyo
Hideyuki Matsumoto: Cellular and Molecular Physiology, Graduate School of Medicine, The University of Tokyo
Nao Ieki: Cellular and Molecular Physiology, Graduate School of Medicine, The University of Tokyo
Takaya Abe: Genetic Engineering Team, RIKEN, Center for Life Science Technologies
Hiroshi Kiyonari: Genetic Engineering Team, RIKEN, Center for Life Science Technologies
Masahiko Morita: Image Processing Research Team, RIKEN
Hideo Yokota: Image Processing Research Team, RIKEN
Nozomi Hirayama: School of Veterinary Medicine, Azabu University
Takahiro Yamazaki: Faculty of Medical Sciences, University of Fukui
Takefumi Kikusui: School of Veterinary Medicine, Azabu University
Kensaku Mori: Cellular and Molecular Physiology, Graduate School of Medicine, The University of Tokyo
Hitoshi Sakano: Faculty of Medical Sciences, University of Fukui

Nature Communications, 2017, vol. 8, issue 1, 1-10

Abstract: Abstract Fox odour 2,4,5-trimethyl thiazoline (TMT) is known to activate multiple glomeruli in the mouse olfactory bulb (OB) and elicits strong fear responses. In this study, we screened TMT-reactive odourant receptors and identified Olfr1019 with high ligand reactivity and selectivity, whose glomeruli are located in the posterodorsal OB. In the channelrhodopsin knock-in mice for Olfr1019, TMT-responsive olfactory-cortical regions were activated by photostimulation, leading to the induction of immobility, but not aversive behaviour. Distribution of photoactivation signals was overlapped with that of TMT-induced signals, but restricted to the narrower regions. In the knockout mice, immobility responses were reduced, but not entirely abolished likely due to the compensatory function of other TMT-responsive glomeruli. Our results demonstrate that the activation of a single glomerular species in the posterodorsal OB is sufficient to elicit immobility responses and that TMT-induced fear may be separated into at least two different components of immobility and aversion.

Date: 2017
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DOI: 10.1038/ncomms16011

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