Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

Sara M. Willems, Daniel J. Wright, Felix R. Day, Katerina Trajanoska, Peter K. Joshi, John A. Morris, Amy M. Matteini, Fleur C. Garton, Niels Grarup, Nikolay Oskolkov, Anbupalam Thalamuthu, Massimo Mangino, Jun Liu, Ayse Demirkan, Monkol Lek, Liwen Xu, Guan Wang, Christopher Oldmeadow, Kyle J. Gaulton, Luca A. Lotta, Eri Miyamoto-Mikami, Manuel A. Rivas, Tom White, Po-Ru Loh, Mette Aadahl, Najaf Amin, John R. Attia, Krista Austin, Beben Benyamin, Søren Brage, Yu-Ching Cheng, Paweł Cięszczyk, Wim Derave, Karl-Fredrik Eriksson, Nir Eynon, Allan Linneberg, Alejandro Lucia, Myosotis Massidda, Braxton D. Mitchell, Motohiko Miyachi, Haruka Murakami, Sandosh Padmanabhan, Ashutosh Pandey, Ioannis Papadimitriou, Deepak K. Rajpal, Craig Sale, Theresia M. Schnurr, Francesco Sessa, Nick Shrine, Martin D. Tobin, Ian Varley, Louise V. Wain, Naomi R. Wray, Cecilia M. Lindgren, Daniel G. MacArthur, Dawn M. Waterworth, Mark I. McCarthy, Oluf Pedersen, Kay-Tee Khaw, Douglas P. Kiel, Yannis Pitsiladis, Noriyuki Fuku, Paul W. Franks, Kathryn N. North, Cornelia M. van Duijn, Karen A. Mather, Torben Hansen, Ola Hansson, Tim Spector, Joanne M. Murabito, J. Brent Richards, Fernando Rivadeneira, Claudia Langenberg, John R. B. Perry, Nick J. Wareham () and Robert A. Scott ()
Additional contact information
Sara M. Willems: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
Daniel J. Wright: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
Felix R. Day: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
Katerina Trajanoska: Erasmus Medical Center
Peter K. Joshi: Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
John A. Morris: Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University
Amy M. Matteini: Johns Hopkins University School of Medicine
Fleur C. Garton: Queensland Brain Institute, University of Queensland
Niels Grarup: The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Nikolay Oskolkov: Lund University Diabetes Center, Diabetes and Endocrinology, Skånes University Hospital
Anbupalam Thalamuthu: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
Massimo Mangino: Kings College London
Jun Liu: Erasmus Medical Center
Ayse Demirkan: Erasmus Medical Center
Monkol Lek: Analytic and Translational Genetics Unit, Massachusetts General Hospital
Liwen Xu: Analytic and Translational Genetics Unit, Massachusetts General Hospital
Guan Wang: Centre for Sport and Exercise Science and Medicine (SESAME), University of Brighton
Christopher Oldmeadow: Hunter Medical Research Institute
Kyle J. Gaulton: University of California San Diego
Luca A. Lotta: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
Eri Miyamoto-Mikami: Japan Society for the Promotion of Science
Manuel A. Rivas: Stanford University
Tom White: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
Po-Ru Loh: BROAD Institute of the Massachusetts Institute of Technology and Harvard University
Mette Aadahl: Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup University Hospital
Najaf Amin: Erasmus Medical Center
John R. Attia: Hunter Medical Research Institute
Krista Austin: Centre for Sport and Exercise Science and Medicine (SESAME), University of Brighton
Beben Benyamin: Queensland Brain Institute, University of Queensland
Søren Brage: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
Yu-Ching Cheng: University of Maryland School of Medicine
Paweł Cięszczyk: Faculty of Physical Education, Gdańsk University of Physical Education and Sport
Wim Derave: Ghent University
Karl-Fredrik Eriksson: Lund University Diabetes Center, Diabetes and Endocrinology, Skånes University Hospital
Nir Eynon: Institute of Sport, Exercise & Active Living (ISEAL), Victoria University
Allan Linneberg: Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup University Hospital
Alejandro Lucia: Universidad Europea de Madrid
Myosotis Massidda: University of Cagliari
Braxton D. Mitchell: University of Maryland School of Medicine
Motohiko Miyachi: National Institutes of Biomedical Innovation, Health and Nutrition
Haruka Murakami: National Institutes of Biomedical Innovation, Health and Nutrition
Sandosh Padmanabhan: British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow
Ashutosh Pandey: Target Sciences, GlaxoSmithKline
Ioannis Papadimitriou: Institute of Sport, Exercise & Active Living (ISEAL), Victoria University
Deepak K. Rajpal: Target Sciences, GlaxoSmithKline
Craig Sale: Musculoskeletal Physiology Research Group, Sport, Health and Performance Enhancement (SHAPE) Research Centre, Nottingham Trent University
Theresia M. Schnurr: The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Francesco Sessa: Medical Genetics, University of Foggia
Nick Shrine: University of Leicester
Martin D. Tobin: University of Leicester
Ian Varley: Musculoskeletal Physiology Research Group, Sport, Health and Performance Enhancement (SHAPE) Research Centre, Nottingham Trent University
Louise V. Wain: University of Leicester
Naomi R. Wray: Queensland Brain Institute, University of Queensland
Cecilia M. Lindgren: BROAD Institute of the Massachusetts Institute of Technology and Harvard University
Daniel G. MacArthur: Analytic and Translational Genetics Unit, Massachusetts General Hospital
Dawn M. Waterworth: Target Sciences, GlaxoSmithKline
Mark I. McCarthy: Wellcome Trust Centre for Human Genetics, University of Oxford
Oluf Pedersen: The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Kay-Tee Khaw: University of Cambridge
Douglas P. Kiel: Harvard Medical School
Yannis Pitsiladis: Centre for Sport and Exercise Science and Medicine (SESAME), University of Brighton
Noriyuki Fuku: Graduate School of Health and Sports Science, Juntendo University
Paul W. Franks: Genetic and Molecular Epidemiology Unit, Lund University, Skånes University Hospital
Kathryn N. North: Murdoch Children’s Research Institute, Royal Children’s Hospital
Cornelia M. van Duijn: Erasmus Medical Center
Karen A. Mather: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
Torben Hansen: The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Ola Hansson: Lund University Diabetes Center, Diabetes and Endocrinology, Skånes University Hospital
Tim Spector: Kings College London
Joanne M. Murabito: Boston University School of Medicine, Section of General Internal Medicine
J. Brent Richards: Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University
Fernando Rivadeneira: Erasmus Medical Center
Claudia Langenberg: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
John R. B. Perry: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
Nick J. Wareham: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
Robert A. Scott: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,180 individuals and identify 16 loci associated with grip strength (P

Date: 2017
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DOI: 10.1038/ncomms16015

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